[Cardiovascular Research] Investigators performed echocardiography, electrophysiology, intracellular Ca2+ imaging, and protein analysis. Female heart failure with preserved ejection fraction (HFpEF) mice exhibited more severe diastolic dysfunction.

[American Journal Of Physiology-Cell Physiology] To assess the effect of the mitochondrial transaminase, glutamic oxaloacetic transaminase (GOT2) on complex II respiration and to determine the effect in intact cells and isolated mitochondria, researchers performed respiratory and metabolic studies in wildtype and CRISPR-generated GOT2 knockdown C2C12 myocytes.

[Respiratory Research] Bioinformatics analysis was employed to screen for potential molecules and mechanisms associated with occurrence and development of pulmonary arterial hypertension.

[Artificial Organs] Calf vascular smooth muscle cells were administered tumor necrosis factor-alpha (TNF-α) before culturing in two- and three-dimensional well plates and polyglycolic acid scaffolds.

[Cellular & Molecular Biology Letters] The authors critically summarize the recent research progress on mitochondrial dynamics and mitophagy in skeletal muscle atrophy, and expound on the intrinsic molecular mechanism of skeletal muscle atrophy caused by mitochondrial dynamics and mitophagy.

[Nature Communications] The authors interrogated CAR-T cells targeting HER2 with either low or high affinity in various preclinical models.

[Nature] By combining epigenomics, transcriptomics and in-pouch marsupial transgenics, scientists showed that Emx2 was a critical upstream regulator of patagium development.

[Tissue Engineering Part A] Cmputational simulations revealed that interfacial fibrils within a bilayer alter osteochondral scaffold deformation patterns by redirecting load-induced stresses toward the top of the cartilage layer.

[Nature Communications] Investigators designed membrane permeant peptide inhibitors that specifically target the primary interface between TANGO1 and cTAGE5, an interaction that is required for collagen export from endoplasmic reticulum exit sites

[Journal Of Agricultural And Food Chemistry] Research indicated that TFDG administration effectively lowered the fasting blood glucose and serum lipid concentrations and enhanced the functionality and cellular architecture of the liver and kidney in rats with diabetes.

[Journal Of Materials Chemistry B] The authors introduce the mechanisms and effects of native extracellular vesicles derived from different cells and tissues to treat liver diseases of different etiologies.

[PLOS One] The authors explored the association of stemness indicators with survival outcomes and clinical characteristics by combining clinical information and survival analyses.