[Journal of Cellular and Molecular Medicine] miR-429-CT10 regulation of kinase-like (CRKL) upregulation was negatively correlated with miR-429 downregulation in both chronic myeloid leemia (CML) patient and CR patient samples.

[Proceedings Of The National Academy Of Sciences Of The United States Of America] By screening nuclear localization signals and nuclear export signals, researchers identified “Myospreader,” a combination of short peptide sequences that promoted myonuclear propagation.

[Cell] The authors described three humans homozygous for a loss-of-function FMS-related tyrosine kinase 3 ligand (FLT3L) G variant with a history of various recurrent infections, including severe cutaneous warts.

[Haematologica] Investigators reported a novel MYH9::PDGFRB fusion in a T-cell lymphoblastic lymphoma patient, and demonstrated that this fusion product was constitutively active and sufficient to drive oncogenic transformation in vitro and in vivo.

[Blood] Researchers analyzed a large group of patients with NPM1mutated AML enrolled in prospective trials to delineate the impact of baseline molecular and clinical features, post induction measurable residual disease status and treatment intensity on outcome.

[Haematologica] DASCERN was a prospective, Phase IIb, randomized trial evaluating a switch to dasatinib in patients who have not achieved early molecular response after three months of treatment with first-line imatinib.

[Hematological Oncology] This study evaluated the efficacy and safety of venetoclax plus hypomethylating agent in a United States community–based outpatient setting in patients with newly diagnosed AML who were treatment naïve for AML.

[Annals Of Hematology] This prospective study involved 80 adult de novo AML patients recruited from Oncology Center, Mansoura University, between March 2019 and July 2021. The MEF2C and EVI1 expression were measured using a Taqman probe-based qPCR assay.

[Provectus Biopharmaceuticals, Inc.] Provectus Biopharmaceuticals, Inc.announced that the United States Patent and Trademark Office has allowed patent application 17/232,393, titled “Halogenated Xanthene Composition and Method for Treating Hematologic Cancers”.

[Cell Stem Cell] Using adult mouse incisors as a model, scientists uncovered the role of Trp53 in regulating vascular composition through THBS2 to maintain mesenchymal tissue homeostasis.

[BMC Musculoskeletal Disorders] Researchers compared miR27a, YTHDF2, and total m6A mRNA levels in steroid-induced necrosis of the femoral head-affected and control bone marrow MSCs. CCK-8 and TUNEL assays were used to assess BMSC proliferation and apoptosis.

[The Journal of Gene Medicine] Exosomes were isolated from human bone marrow MSCs (hBMSC), and keloid fibroblasts (KFs) were treated with exosomes derived from hBMSC. Cell counting kit-8, wound healing, transwell invasion, immunofluorescence, and western blot assays were conducted to study the malignant phenotype of KFs.