[Advanced Functional Materials] Investigators revealed that MgFe-layered double hydroxide (LDH) had bidirectional regulatory effects on the differentiation of mESCs into neural progenitor cells, essentially suppressing cell differentiation on the first day and promoting cell differentiation on the third day.

[Science Advances] Investigators identified mechanisms that subsequently regulated germ plasm assembly in the early embryo. They showed that the Smaug RNA binding protein was transported into the germ plasm of the early embryo where it accumulated in the germ granules.

[Stem Cells and Development] In the selection of low- and high-density inoculation conditions, scientists found that low-density culture performed better in the final red blood cell product with more cell output and increased average cellular hemoglobin content.

[International Journal of Stem Cells] Researchers investigated the effects of acetaldehyde dehydrogenase 2 (ALDH2) mutations on bone remodeling. They examined the effects of ALDH2 polymorphisms on in vitro osteogensis using hiPSCs.

[Nature Genetics] Recent high-throughput sequencing studies have revealed that mosaicism is common, clone sizes often increase with age and specific variants can affect tissue function and disease development.

[Trends in Cell Biology] The authors provide an update with a focus on H3.3 functions in early mammalian development, considering the context of ESC maintenance and differentiation, to finally conclude with emerging roles in cancer development and cell fate transition and maintenance.

[SCG Cell Therapy] SCG Cell Therapy and the Agency for Science, Technology and Research (A*STAR) announced the launch of joint laboratories for cellular immunotherapies. This collaboration,aims to advance the development of iPSC technology to produce novel cell therapies that meet GMP standards.

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Investigators generated five different genomic excisions at the C9orf72 locus in a patient-derived iPSC line and a non-diseased wild-type line, and examined gene expression and pathological hallmarks of C9 frontotemporal dementia/ALS in motor neurons differentiated from these lines.

[Cell Death & Disease] The authors demonstrated that a nanocarrier, named The-0504, could cross the blood-brain barrier and specifically deliver the payload to gliomas that express high amounts of the ferritin/transferrin receptor TfR1 (CD71).

[Science Advances] Scientists used proteomics, genetics, and translation assays in cultured cells and mouse brains to reveal altered translation mediated by loss of the kinase TAOK2 in 16p11.2 deletion models.

[Journal Of Neuro-Oncology] Four patient-derived pediatric glioma models were investigated to model rebound growth in vitro based on viable cell counts in response to mitogen-activated protein kinase (MAPK) inhibitor (MAPKi) treatment and withdrawal.

[Signal Transduction And Targeted Therapy] Scientists analyzed pancreatic lesions in autopsy tissues from SARS-CoV-2 infected non-human primates (NHPs) models and vaccinated and infected NHPs from 2020 to 2023.