[Experimental & Molecular Medicine] Researchers identified MAP3K3 as a target for overcoming anticancer drug resistance. Depletion of MAP3K3 led to a substantial reduction in the yes-associated protein (YAP) protein level in melanoma and breast cancer cells.

[International Journal Of Cancer] The authors found that melanoma cells with high basal poly (ADP-ribose) polymerase (PARP1) expression exhibited significantly increased cell death after PARP inhibitor treatment, owing to higher PARP1 trapping compared with melanoma cells with low PARP1 expression.

[Communications Biology] Scientists demonstrated that all-trans-retinoic acid (ATRA) signaling cycles during hair follicle regeneration. This pattern was disrupted by genetic deletion of epidermal retinol dehydrogenases 2 (RDHE2) and RDHE2-similar that catalyzed the rate-limiting step in ATRA biosynthesis.

[Proceedings Of The National Academy Of Sciences Of The United States Of America] The authors showed that keratinocyte extracellular vesicles enhanced the ability of melanocytes to generate dendrites and mature melanosomes and promoted their efficient transfer.

[Science Advances] Researchers demonsrated that metformin engineered extracellular vesicles could enhance aged mouse skin repair, as well as ameliorate cellular senescence and restore cell dysfunctions.

[Cell Reports] Using different in vitro models of alternative BRAF mRNA isoforms (altBRAF)-mediated melanoma resistance, researchers demonstrated the production of altBRAFs exclusively from the BRAF V600E allele, correlating with corresponding genomic deletions.

[Cellular & Molecular Biology Letters] The authors evaluated the therapeutic efficacy of RC48, alone or in combination with dabrafenib, in BRAF-mutant cutaneous melanoma cell lines and cell-derived xenograft models.

[Palisade Bio, Inc.] Palisade Bio, Inc. announced the completion of its analysis evaluating ex-vivo bioactivation of PALI-2108, an orally administered, locally acting colon-specific phosphodiesterase-4 inhibitor prodrug in development for patients affected by ulcerative colitis (UC). PALI-2108 exhibited efficient ex-vivo conversion into its active PDE4 inhibitor form in stool samples from both normal healthy volunteers and patients with UC.

[Case Western Reserve University] With a new five-year, $1.84 million grant from the National Cancer Institute, researchers from Case Western Reserve University hope to take a step closer to developing new treatment options for people with metastatic colorectal cancer by studying how a protein involved in colorectal cancer growth functions.

[BMC Medicine] Phosphatidylinositol-3,4,5-triphosphate-dependent Rac exchange factor 2 (PREX2) emerged as a significantly upregulated gene in radioresistant colorectal cancer (CRC) cells. It augmented the radioresistant capacity of CRC cells and demonstrated potential as a marker for predicting radioresistance efficacy.

[Oncogene] Overexpression of lysine-specific demethylase 6A (KDM6)AA694T in colorectal signet-ring cell carcinoma (SRCC) cell line promoted cell proliferation, invasion and migration, which were further confirmed in vivo by constructing orthotopic tumor growth and lung metastasis models.

[Gut] Scientists developed a model to study the function of a fusion protein in the pathogenesis of diffuse gastric cancer (DGC). Using organoids generated from this model, they evaluated its oncogenic activity and the biochemical effects of the fusion protein on the RHOA pathway and its downstream cell biological effects in the pathogenesis of DGC.