Keep Current with the Latest in Cell Biology Research

ATG or Post-Transplant Cyclophosphamide to Prevent GVHD in Matched Unrelated Stem Cell Transplantation?

[Leukemia] Investigators analyzed outcomes of abbit anti-thymocyte globulin vs. post-transplantation Cyclophosphamide prophylaxis in adult patients with hematologic malignancies undergoing peripheral blood allogeneic stem cell transplantations from 10/10 antigen-matched unrelated donors between January 2018 and June 2021 in the EBMT database.

Mapping Cell-to-Tissue Graphs Across Human Placenta Histology Whole Slide Images Using Deep Learning With HAPPY

[Nature Communications] The authors developed the ‘Histology Analysis Pipeline.PY’ (HAPPY), a deep learning hierarchical method for quantifying the variability of cells and micro-anatomical tissue structures across placenta histology whole slide images.

Joints That Could Heal Themselves? Researchers Could Get There in 5 Years

[University of Colorado] At the first inkling of a creaky knee, patients could get a single shot in the joint that would not only stop their cartilage and bone from eroding, but kick start its regrowth. That may seem like a dream, but the Advanced Research Projects Agency for Health awarded up to $39 million to a University of Colorado Boulder-led team of scientists to work toward making it a reality.

Mechanical Properties of Native and Decellularized Reproductive Tissues: Insights for Tissue Engineering Strategies

[Scientific Reports] Researchers investigated the changes in Young's modulus, storage modulus, loss modulus, and porosity of native and decellularized bovine reproductive tissues during the estrous cycle.

TGR5-Mediated Lateral Hypothalamus-dCA3-Dorsolateral Septum Circuit Regulates Depressive-Like Behavior in Male Mice

[Neuron] Using depression models of chronic social defeat stress and chronic restraint stress in male mice, researchers found that TGR5 in the lateral hypothalamic area predominantly decreased in GABAergic neurons, the excitability of which increased in depressive-like mice.

Feedforward and Feedback Mechanisms Cooperatively Regulate Rapid Experience-Dependent Response Adaptation in a Single Thermosensory Neuron Type

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Researchers showed that rapid thermosensory response adaptation in AFD was mediated via cGMP and calcium-dependent feedforward and feedback mechanisms operating at the level of primary thermotransduction.

Glucosylceramide Accumulation in Microglia Triggers STING-Dependent Neuroinflammation and Neurodegeneration in Mice

[Science Signaling] Scientists investigated the mechanisms by which glucosylceramide (GC) accumulation induced neuroinflammation. They found that GC accumulation within microglia induced by pharmacological inhibition of GCase triggered STING-dependent inflammation, which contributed to neuronal loss both in vitro and in vivo.

Prosaposin Maintains Adult Neural Stem Cells in a State Associated with Deep Quiescence

[Stem Cell Reports] Using RNA sequencing and pharmacological manipulations, investigators showed that lysosomes were necessary for neural stem cell quiescence maintenance.

The Dynamics of Notch Signaling in the Neuron-Glia Switch: A Balancing Act

[Journal Of Neurophysiology] The author offersseveral suggestions for future research investigating the precise spatiotemporal control of Notch signaling throughout the development of the central nervous system.

Genetically Engineered Marmosets Promise Insight into Early Stages of Parkinson’s

[Science] A cohort of transgenic marmoset models may help predict neurological conditions and test potential treatments.

Dux Activates Metabolism-Lactylation-MET Network during Early iPSC Reprogramming with Brg1 as the Histone Lactylation Reader

[Nucleic Acids Research] Scientists demonstrated that the modification of H3K18la induced by Dux overexpression controlled the metabolism-H3K18la-MET network, enhancing the efficiency of iPSC reprogramming through a metabolic switch and the recruitment of p300 via its C-terminal domain.

Preparation of Human Astrocytes with Potent Therapeutic Functions from Human Pluripotent Stem Cells Using Ventral Midbrain Patterning

[Journal of Advanced Research] To substantiate the clinical application of astrocyte-based therapy, researchers prepared human astrocytes with potent therapeutic capacities from hPSCs. They used ventral midbrain patterning during the differentiation of hPSCs into astrocytes.

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