[Molecular Therapy - Nucleic Acids] To identify CD3-specific T cell agonists, several RNA aptamers were selected against CD3 using SELEX combined with high-throughput sequencing.

[Cell Reports Medicine] Scientists presented a metabolic refueling approach using inosine as an alternative fuel. CAR T cells were engineered to express membrane-bound CD26 and cytoplasmic adenosine deaminase 1 (ADA1), converting adenosine to inosine.

[Molecular Therapy] Researchers developed a controllable cell therapy where synthetic D-Domain-containing proteins (SparX) bind one or more tumor antigens and mark those cells for elimination by genetically modified T cells

[Proceedings Of The National Academy Of Sciences Of The United States Of America] The mosquito-transmitted Nodamura virus was attenuated in mice by mutations that prevent expression of the B2 viral suppressor of RNA interference and consequently, drastically enhance in vivo production of the virus-targeting small-interfering RNAs.

[International Journal Of Biological Macromolecules] The authors compare the effectiveness of 3D suspended fiber scaffolds with 2D culture systems, discussing their respective benefits and limitations in the context of tissue regeneration.

[Advanced Healthcare Materials] An injectable tissue engineering scaffold consisting of highly porous microspheres compatible with transplantation of cells was modified to contain the computed tomography contrast agent barium sulphate.

[Cancer Immunology Immunotherapy] CD8TM.41BBIC-based anti-BCMA CAR vectors with either a long linker or a short linker between the light and heavy scFv chain, CD28TM.41BBIC-based and CD28TM.CD28IC-based anti-BCMA CAR vector systems were used in primary human T cells.

[Expert Review Of Anticancer Therapy] Scientists highlight important differences in clinical outcomes between CAR T-cell therapies. Axi-cel demonstrated improved overall survival compared to tisa-cel and liso-cel, and both axi-cel and liso-cel showed higher response rates compared to tisa-cel.

[Hong Kong Polytechnic University (EurekAlert!)] The Hong Kong Polytechnic University has entered into a formal collaboration with Axis Therapeutics to foster cancer immunotherapy research and development, with the aim of improving cancer treatment for patients in Hong Kong.

[Journal For Immunotherapy Of Cancer] The authors developed a second-generation CAR directing CD19 and CD20 antigens, incorporating them in a head-to-head orientation from a bidirectional promoter using a single Sleeping Beauty transposon system.

[Heliyon] The levels of NAT10 in normal colon and chemoresistant colon cancer tissues were determined utilizing quantitative real-time polymerase chain reaction alongside immunohistochemistry.

[Nature Communications] Using a combination of transcriptomic, proteomic, and phosphoproteomic analyses, longitudinal imaging, organotypic cultures, functional assays, animal studies, and clinical data analyses, we demonstrate that chemoradiation and brain vasculature induce cell transition to a functional state named VC-Resist.