[JD Bioscience (ChosunBiz)] The Gwangju Institute of Science and Technology (GIST) noted that the new drug candidate 'GM-60106', developed by JD BioScience, received global clinical Phase IIa trial plan approval from the US FDA.

[Beam Therapeutics] Beam Therapeutics Inc. announced that the US FDA has granted orphan drug designation to BEAM-302, a liver-targeting lipid-nanoparticle formulation of a guide RNA and an mRNA encoding a base editor designed to correct the disease-causing mutation in patients with AATD.

[Nature] Investigators showed that the subfornical organ of the brain is a nucleus for parenchymal αβ T cells in the steady-state brain in both mice and humans.

[Immunity] Scientists revealed mechanisms of tissue-resident memory CD8⁺ T cell-like tumor-infiltrating lymphocytes differentiation and provide a framework for considering tissue residency in the context of CD8⁺ T cell heterogeneity in the tumor microenvironment.

[Science Translational Medicine] Scientists found that Treg-extracellular vesicles from healthy individuals inhibit CD4⁺ conventional T cells by shuttling miR-142-3p from the Treg cell to the Tconv cell.

[Science Translational Medicine] Researchers investigated the role and origin of specific Treg lineages in allergen-specific immunotherapy with human atopic dermatitis (AD) samples and with a mouse model of AD.

[Nature Communications] Using preclinical mouse models, investigators showed that, following HBsAg expression, the intrahepatic Batf3⁺XCR1⁺CCR7^- conventional dendritic cell subset cDC1 presents HBsAg by MHC-I cross-dressing, driving CD8⁺ T cell response.

[Advanced Healthcare Materials] To address challenges with current rheumatoid arthritis therapies, an interleukin-4-tethered, hyaluronic acid-based hydrogel was developed that withstands repeated mechanical stress in the joint space while fostering an immunomodulatory environment.

[Cell Death & Disease] Investigators employed primary or subcutaneous mouse hepatocellular carcinoma (HCC) models and flow cytometry to study the impact of conditional knock-in of Ltbr on CD4⁺ T cell differentiation and response, particularly the Th17/Treg cell ratio, and its influence on HCC progression.

[Molecular Medicine Reports] An experimental mouse model of allergic rhinitis was established by sensitizing and exposing the mice to allergens, followed by the administration of indolepropionic acid via gavage.

[Cardiology] Researchers elucidated the impact of tissue inhibitor of metalloproteinase-4 (TIMP4) on heart failure pathogenesis, with a particular emphasis on its influence on T helper 17 and Treg lymphocyte populations.

[Naunyn-Schmiedebergs Archives of Pharmacology] The authors explore the integral role of the let-7 family of microRNAs in mediating tumor immune evasion, particularly how these regulators influence the tumor microenvironment and immune cell functionality.