[BMC Cancer] Through bioinformatics analysis, researchers discovered a previously unstudied differential gene called HIST3H2A in prostate cancer (PCa). They revealed that HIST3H2A was highly expressed in PCa tissues, as confirmed by analysis of both the GEO and UALCAN databases.

[British Journal of Pharmacology] Human fibrocytes were isolated from peripheral blood of six healthy donors. Recombinant human (rh)-IL-11 and soluble rh-IL-11 receptor, α subunit were used to stimulated fibrocytes in vitro to measure cell migration in a chemotactic migration chamber among other variables.

[Journal of Cancer Research and Clinical Oncology] The core 1β1,3-galactosyltransferase 1 (C1GALT1) expression and its clinical relevance were investigated through public databases and lung adenocarcinoma tissue microarray analyses.

[Biology Open] The authors showed that serine/arginine repetitive matrix 2 (Srrm2) dosage was critical for maintaining ESC pluripotency and cell identity.

[Stem Cell Research & Therapy] Investigators review the progress of haploid ESC research and briefly discuss the applications of haploid ESCs.

[Signal Transduction and Targeted Therapy] The authors outline key developments in the iPSC field and highlight the immense versatility of the iPSC technology for in vitro modeling and therapeutic applications.

[Molecular Biology Reports] Wharton’s Jelly-derived-MSCs were isolated from human umbilical cord. The cells were incubated according to the standard culture conditions and characterized by flow cytometry.

[Stem Cell Research & Therapy] Single cell human small intestine organoids were embedded in Matrigel, grown for five days and treated with busulfan for 48 hours.

[Stem Cell Research & Therapy] Recombinant human bone morphogenetic protein 2 (rhBMP-2) and human bone marrow MSCs were tested in an in vivo subcutaneous implantation model to assess their ability to form mature bone and undergo multilineage differentiation.

[Cell] Investigators compared perinatal and adult bone marrow MSCs. MSCs exhibited enrichment in genes mediating m6A mRNA methylation at the perinatal stage and downregulated the expression of Mettl3 shortly after birth.

[Cancer Immunology Research] Researchers designed MP0533, a multispecific CD3-engaging designed ankyrin repeat protein that could simultaneously bind to three antigens on AML cells, CD33, CD123, and CD70, aiming to enable avidity-driven T cell–mediated killing of AML cells co-expressing at least two of the antigens.

[Molecular Cell] The authors utilized synthetic introns uniquely responsive to mutant SF3B1 to identify trans factors required for aberrant mutant SF3B1 splicing activity.