[Nature Communications] Investigators showed that β cells within stem cell-derived islets gradually undergo a decline in cell identity and metabolic function in hypoxia.

[Nature Communications] The authors showed that the a posteriori enhancement increased transgene output without expansion of hepatocytes bearing lentiviral vector genomic integrations near cancer genes, in mouse models of hemophilia, an inherited coagulation disorder.

[Nature Reviews Cardiology] Investigators describe the rationale for gene therapy to treat cardiac arrhythmias and discuss advantages and disadvantages of gene silencing, gene replacement, gene suppression-and-replacement and gene editing technologies.

[JCI Insight] Through generation of bone marrow chimeric mice, researchers showed that STING^-/- mice receiving wild-type bone marrow are protected against pulmonary hypertension secondary to chronic hypoxia.

[Circulation Research] Exercise enhances metabolic health by promoting muscle growth, mitochondrial biogenesis, and improved nutrient storage while preventing age-related muscle dysfunction.

[Science Advances] Researchers characterized nasal airway epithelial cell (NAEC) developmental phenotypes from children aged 2 to 3 years in an a priori designed nested birth cohort from four mutually exclusive groups of wheezers/nonwheezers and respiratory syncytial virus–infected/uninfected in the first year of life.

[Science Advances] Investigators identified a small nucleolar RNA (Snora54) that was highly expressed in the nucleolus of intestinal stem cells (ISCs). Snora54 knockout enhanced the self-renewal capacity of ISCs and intestinal regeneration.

[Scientific Reports] Researchers cultured human umbilical cord MSCs (hUCMSC) in vitro and treated them with 635/808 nm laser light. The results showed that photobiomodulation treatment significantly enhances hUCMSC proliferation and osteogenic differentiation.

[Cell Death & Differentiation] Scientists found NADH dehydrogenase [ubiquinone] iron-sulfur protein 3 (NDUFS3) were abnormally elevated in human melanoma and promoted melanoma proliferation.

[Nature Structural & Molecular Biology] Investigators revealed that DEK safeguards mESCs from acquiring primitive endoderm fates by modulating the repressive histone mark H3K27me3.

[Cell Death Discovery] Researchers showed that matrix metalloproteinase-10 promotes kidney fibrosis by trans-activating β-catenin via the epidermal growth factor receptor signaling.

[Molecular Cancer] Researchers explore recent advances in understanding how niche factors regulate cell fate determination between skin stem cells and skin cancer stem cells, along with their clinical implications.