[Journal Of Clinical Investigation] Scientists developed a mouse model of sedentariness, small mouse cage that, unlike other classic models of disuse in mice, faithfully recapitulated metabolic responses that occured in humans.

[New England Journal Of Medicine] The authors conducted an open-label, single-group, Phase III study of exa-cel in patients 12 to 35 years of age with transfusion-dependent β-thalassemia and a β0/β0, β0/β0-like, or non–β0/β0-like genotype.

[Cancer Cell] Investigators reported that p53 was activated following BH3-mimetic induced mitochondrial outer membrane permeabilization, leading to BH3-only protein induction and thereby potentiating the pro-apoptotic signal.

[EMBO Reports] Researchers examined mESC lines with an inducible Xist allele and integrated allele-specific data of gene silencing and decreasing inactive X chromatin accessibility over time courses of Xist induction with cellular differentiation.

[Nucleic Acids Research] Scientists presented a precise and programmable method called prime editor–mediated correction of nucleotide repeat expansion for correcting pathogenic nucleotide repeat expansion.

[Journal of Cell Biology] Scientists demonstrated that Brg1 loss profoundly impaired oligodendrocyte-precursor cell (OPC) differentiation in the brain with a comparatively lesser effect in the spinal cord. Moreover, BRG1 was critical for OPC remyelination after injury.

[Advanced Materials] To effectively inhibit aerobic glycolysis, increase drug delivery efficiency, and improve drug sensitivity, researchers successfully designed and prepared a novel TMZ nanocapsule for the combined delivery of siPKM2 and TMZ.

[Cancer Research] Researchers identified a circRNA derived from MYBL1 pre-mRNA that accompanied overexpression of MYBL1 in adenoid cystic carcinoma (ACC). Overexpression of circMYBL1 was correlated with increased lung metastasis and poor overall survival in ACC patients.

[Future Oncology] Investigators focus on the role of CD39 and CD73 in immune response and malignant progression, including the expression of CD39 within the tumor microenvironment and its relationship to immune effector cells, and its role in antigen presentation.

[Journal of Cellular Physiology] The authors review the multifaceted functions of B cells in atherosclerosis, with a specific focus on HIV. Unique to atherosclerosis is the pivotal role of natural antibodies, particularly those targeting oxidized epitopes abundant in modified lipoproteins and cellular debris.

[Weill Cornell Medicine] Dr. Ashley Nelson has received a 2023 Hartwell Individual Biomedical Research Award from The Hartwell Foundation. The award provides $100,000 direct cost support per year for three years and designation as a Hartwell Investigator.

Scientists showed that intestinal-epithelial intrinsic expression of lysine-specific demethylase 1A (LSD1) was necessary for the postnatal maturation of intestinal epithelium and maintenance of this...