[Molecular Neurodegeneration] Investigators evaluated neuroretinal degeneration, gliosis, subretinal space phagocyte infiltration, and retinal pigmented epithelium morphology through immunofluorescence analysis.

[Clinical Immunology] Scientists performed single-cell RNA sequencing and single-cell VDJ sequencing to generate transcriptional profiles for cells and T/B cell clonetype in skin lesions of bullous pemphigoid and pemphigus vulgaris.

[Pediatrics] This retrospective cohort study examined children ages 1 to 16 within the Children’s Hospital of Philadelphia Care Network who received PCR testing for SARS-CoV-2 between March 1, 2020 and February 28, 2021.

[JCI Insight] Researchers profiled people with HIV and uninfected controls through single-cell transcriptomic and T cell receptor sequencing to understand the dynamics of HIV persistence in the central nervous system.

[Annals Of The Rheumatic Diseases] TNF-α was a key determinant for B10 cells. TNF-α elicited the proinflammatory feature of B10 and B10pro cells by downregulating IL-10, and upregulating interferon-γ and IL-17A.

[Hudson Institute of Medical Research (Mirage News)] Director and CEO Professor Elizabeth Hartland announced that Professor Carl Walkley and Dr Sophia Davidson will join the Institute's Centre for Innate Immunity and Infectious Diseases (CiiiD) as Research Group Heads, bringing impressive resumés and exciting research opportunities with them.

[Radcliffe Department of Medicine] A team led by Professor Graham Ogg, Deputy Director of the MRC Translational Immune Discovery Unit and Leader of the Translational Dermatology Unit, alongside Professor Jamie Rossjohn, Professor Branch Moody, Professor Muzlifah Haniffa, and Professor Gurdyal Besra, have received a Wellcome Discovery Award to investigate how immune cells contribute to inflammation.

[Nucleic Acids Research] Investigators demonstrated that in heart failure patient cardiomyocytes, telomeres were shortened compared to healthy controls.

[Scientific Reports] The authors elucidated the mechanisms by which myopathy and dilated cardiomyopathy develop using the murine myoblast cell line C2C12 and disease-specific human induced pluripotent stem cells.

[Nature] Scientists found that activation of the pore-forming protein GSDMD by the cytosolic lipopolysaccharide (LPS) sensor caspase-11, but not by TLR4-induced cytokines, mediated BBB breakdown in response to circulating LPS or during LPS-induced sepsis.

[Cancer Gene Therapy] Researchers screened for differentially expressed genes in osteosarcoma. They found that osteosarcoma cases could be divided into fair and poor survival groups based on gene expression profiles.

[Cell Death & Disease] Caspase 8 (Casp8) is a master regulator of pyroptosis, apoptosis, and necroptosis (PANoptosis). To study the role of PANoptosis in hematopoiesis, scientists generated inducible Casp8 knockout mice.