[Apoptosis] Investigators identified for the first time the potential effect of MIR210HG on disease progression in hypoxic pulmonary hypertension.

[Journal Of Cardiovascular Translational Research] The authors review mitochondria's multifaceted role in cardiac regeneration, particularly in myocardial infarction and heart failure models.

[Blood] Researchers investigated the role of tRNA pseudouridylation in erythropoiesis and its association with mitochondrial myopathy, lactic acidosis, and sideroblastic anemia syndrome pathogenesis.

[Blood] Scientists combined single cell RNA-seq and single cell ATAC-seq to decipher the trajectories involved in plasma cell differentiation.

[Cell Reports] The authors developed a method to capture and sequence newly synthesized RNA in early mouse embryos, providing a view of transcriptional reprogramming during zygotic genome activation.

[JCI Insight] Scientists generated retinal organoids from iPSCs derived from patients with eyes shut homolog (EYS)-associated retinal dystrophy.

[Cell Reports] Researchers delineated the dynamics of TFAP2C during the mouse peri-implantation stage and elucidated its collaboration with the key lineage regulators CDX2 and NANOG.

[Small] Microfluidics and two-photon confocal microscopy was applied to screen nanocarriers for transport efficacy and gain mechanistic insights into their interactions with neurons.

[Scientific Reports] A series of 20 novel gefitinib derivatives incorporating the 1,2,3-triazole moiety were designed and synthesized. The synthesized compounds were evaluated for their potential anticancer activity against epidermal growth factor receptor wild-type human NSCLC cells and human lung adenocarcinoma cells as NSCLC.

[Journal Of Proteome Research] Investigators found that pirin was upregulated in NSCLC, and its expression was positively correlated with poor prognosis. Overexpression of pirin inhibited autophagy and promoted NSCLC proliferation.

[Cell] Researchers found that SARS-CoV-2 evaded NKG2D recognition by surface downregulation of MIC-A/B via shedding, observed in human lung tissue and COVID-19 patient serum.

[Small] The authors discuss the recent advancements in the application of extracellular vesicle (EV) therapies and highlight EV-based functional materials as novel interventions for prostate cancer.