[Science Advances] Investigators engineered a Cellular Trojan Horse, named MetaCell, which used live neutrophils to stably internalize thermosensitive liposomal bimetallic Fe-Cu MOFs. MetaCell could instigate cuproptosis and ferroptosis, thereby enhancing treatment efficacy.

[Biomedicine & Pharmacotherapy] Scientists designed and characterized a novel bispecific antibody based on the IgG-(L)-ScFv format, which targeted L1CAM and CD3 simultaneously.

[Journal For Immunotherapy Of Cancer] Researchers tested a series of antibodies raised against the CA125 extracellular repeat domain of MUC16 and adapted them to the CAR format. Comparisons between these candidates, and against an existing CAR targeting the MUC16 ectodomain, identified K101 as having high potency and specificity.

[Nature Communications] Scientists comprehensively profiled 100 human uveal melanoma metastases using clinicogenomics, transcriptomics, and tumor infiltrating lymphocyte potency assessment.

[Annals Of The Rheumatic Diseases] Single-cell RNA and T cell receptor sequencing were performed on renal biopsy tissues from 40 patients with lupus nephritis and 6 healthy donors as controls. Matched peripheral blood samples from seven LN patients were also sequenced.

[Clinical & Experimental Metastasis] Scientists assessed the immune cell composition of peri-implantitis and periodontitis lesions and the corresponding inflammatory profile in soft tissues and crevicular fluid. Peri-implantitis, periodontitis and control patients were recruited, and soft tissue biopsies were collected during surgery.

[Molecular Medicine] The authors investigated CD4+ and CD8+ T lymphocytes from the synovial tissue and peripheral blood of patients with treatment-resistant immune-mediated arthritis using paired single-cell RNA and TCR-sequencing.

[International Journal Of Oral Science] Using single-cell RNA sequencing data from the Gene Expression Omnibus database, the study identified distinct gene expression patterns in tumor-infiltrating B cells (TIL-BAs). Head and neck squamous cell carcinoma samples were categorized into TIL-Bs inhibition and TIL-Bs activation groups using unsupervised clustering.

[Advanced Healthcare Materials] The authors cover the state of the art in the intricate landscape of immune organs-on-chip models, shedding light on the pivotal role of biofabrication technologies in bridging the gap between conceptual design and physiological relevance.

[CPT-Pharmacometrics & Systems Pharmacology] Weighted gene coexpression network analysis helped identify memory CD4+ T cell–associated gene modules. Combined with module genes, a five-gene lung adenocarcinoma prognostic risk model was constructed by regression analysis.

[Goethe University Frankfurt (EurekAlert!)] Biochemist and structural biologist Robert Tampé, a specialist in the structural analysis of membrane protein complexes of the adaptive immune system, has now been awarded a five-year, €2.5 million European Research Council Advanced Grant for his project Unraveling the Supramolecular Architecture of Molecular Machineries in Adaptive Immunity

[Harvard Medical Soon] Sooner than you may think, says Dr. Catherie Wu, Harvard Medical School professor of medicine and, was honored in February with the $1 million Sjöberg Prize, given for cancer research.