Keep Current with the Latest in Cell Biology Research

Metformin Boosts Anti-tumor Immunity and Improves Prognosis in Upfront Resected Pancreatic Cancer: An Observational Study

[JNCI-Journal Of The National Cancer Institute] Researchers investigated the influence of metformin on patient survival and its potential correlation with distinct immune profiles in PDAC tumors.

Unveiling the Role of PYGB in Pancreatic Cancer: A Novel Diagnostic Biomarker and Gene Therapy Target

[Journal Of Cancer Research And Clinical Oncology] Scientists constructed a risk diagnostic model of pancreatic cancer (PC)-related genes by WGCNA and LASSO regression and found PYGB, an essential gene in PC. Then, we explored the pro-carcinogenic role of Brain glycogen phosphorylase in PC by in vivo and in vitro experiments.

Rintatolimod in Advanced Pancreatic Cancer Enhances Anti-Tumor Immunity through Dendritic Cell-Mediated T Cell Responses

[Clinical Cancer Research] Investigators studied the effect of TLR-3 activation through rintatolimod on the peripheral immune landscape of advanced PDAC patients.

The BulkECexplorer Compiles Endothelial Bulk Transcriptomes to Predict Functional versus Leaky Transcription

[Nature Cardiovascular Research] Researchers presented the BulkECexplorer compendium of 240 bulk RNA-seq datasets from five vascular endothelial cell subtypes. This resource reported transcript counts for genes of interest and predicts whether detected transcripts were likely the products of active or leaky gene expression.

Myricetin Oligomer Triggers Multi-Receptor Mediated Penetration and Autophagic Restoration of Blood-Brain Barrier for Ischemic Stroke Treatment

[ACS Nano] Post ischemic stroke, hypoxia/hypoglycemia provoked the up-regulation of transmembrane glucose transporters and iron transporters due to multiple metabolic disorders, especially in brain endothelial cells. Scientists developed a myricetin oligomer-derived nanostructure doped with Ce to bypass the blood-brain barrier which was cointermediated by glucose transporters and iron transporters such as glucose transporters 1, sodium/glucose cotransporters 1, and transferrin reporter.

Sensitive Detection of Multiple Blood Biomarkers via Immunomagnetic Exosomal PCR for the Diagnosis of Alzheimer’s Disease

[Science Advances] An immunomagnetic exosomal polymerase chain reaction platform was developed using DNA-conjugated antibodies for the rapid detection of amyloid-β and phosphorylated tau in clinical blood exosomes.

Past and Future of Alveolar Organoids for Lung Regenerative Medicine

[Stem Cells] The authors cover research focused on alveolar epithelial cells and discuss methods expected to regenerate lungs that are damaged by diseases.

Advances and Applications of Cancer Organoids in Drug Screening and Personalized Medicine

[Stem Cell Reviews And Reports] Scientists explored the evolution of cancer organoids and emphasized the significant role these models play in fundamental research and the advancement of personalized medicine in oncology.

Researcher’s Microscale Tech Is Chipping Away at Cancer, Organ Failure and Neurological Disease

[Arizona State University] Arizona State University’s Mehdi Nikkhah is a pioneer in organ-on-a-chip technologies. For his outstanding contributions to the engineering of biomimetic tissue-on-chip technologies and organoids for disease modeling and regenerative medicine, Nikkhah was inducted as a fellow into the American Institute for Medical and Biomedical Engineering.

CGRP Sensory Neurons Promote Tissue Healing via Neutrophils and Macrophages

[Nature] Scientists showed that ablation of the NaV1.8 nociceptor impairs skin wound repair and muscle regeneration after acute tissue injury. Nociceptor endings grew into injured skin and muscle tissues and signal to immune cells through the neuropeptide calcitonin gene-related peptide (CGRP) during the healing process.

ATG or Post-Transplant Cyclophosphamide to Prevent GVHD in Matched Unrelated Stem Cell Transplantation?

[Leukemia] Investigators analyzed outcomes of abbit anti-thymocyte globulin vs. post-transplantation Cyclophosphamide prophylaxis in adult patients with hematologic malignancies undergoing peripheral blood allogeneic stem cell transplantations from 10/10 antigen-matched unrelated donors between January 2018 and June 2021 in the EBMT database.

Mapping Cell-to-Tissue Graphs Across Human Placenta Histology Whole Slide Images Using Deep Learning With HAPPY

[Nature Communications] The authors developed the ‘Histology Analysis Pipeline.PY’ (HAPPY), a deep learning hierarchical method for quantifying the variability of cells and micro-anatomical tissue structures across placenta histology whole slide images.

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