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SCIENCE NEWS
Protein Could Heal Erectile Dysfunction After Cancer Surgery
After men have surgery to remove a cancerous prostate gland, up to 80 percent of them will lose the ability to have an erection because of damage to a critical nerve that runs along the prostate. New research shows the damaged nerve can be regenerated more quickly with the sonic hedgehog protein delivered via a nanofiber gel. [Press release from the Northwestern University Feinberg School of Medicine discussing research presented at the American Urological Association 2010 Annual Meeting]
Genetic Markers Could Predict Prostate Cancer in Younger Men, Study Finds
Prostate cancer has become more common in younger men, and it's often more aggressive in these men. A new study has found that a series of genetic mutations could help detect this early onset prostate cancer. [Press release from the University of Michigan Comprehensive Cancer Center discussing research presented at the 46th Annual Meeting of the American Society of Clinical Oncology (ASCO)]
Delay in Surgery Not Likely to Worsen Tumors in Men with Low-Risk Prostate Cancer
Johns Hopkins experts have found that men enrolled in an active surveillance program for prostate cancer that eventually needed surgery to remove their prostates fared just as well as men who opted to remove the gland immediately, except if a follow-up biopsy during surveillance showed high-grade cancer. [Press release from EurekAlert! discussing research presented at the 46th Annual Meeting of the American Society of Clinical Oncology (ASCO)]
Blood Vessel-Blocking Drug Slows Prostate Cancer Progression: Experts
A blood vessel-blocking drug called tasquinimod slowed the rate of disease progression in a clinical trial of 200 prostate cancer patients, according to experts at Johns Hopkins, Roswell Park Cancer Institute and Duke University. [The Medical News]
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LABORATORY RESEARCH
Rearrangements of the RAF Kinase Pathway in Prostate Cancer, Gastric Cancer and Melanoma
Taken together, the results emphasize the key role of RAF family gene rearrangements in cancer, suggest that RAF and MEK inhibitors may be useful in a subset of gene fusion-harboring solid tumors and demonstrate that sequencing of tumor transcriptomes and genomes may lead to the identification of rare targetable fusions across cancer types. [Nat Med]
Molecular Interplay of the Noncoding RNA ANRIL and Methylated Histone H3 Lysine 27 by Polycomb CBX7 in Transcriptional Silencing of INK4a
Here researchers report that chromobox 7 (CBX7) within the polycomb repressive complex 1 binds to ANRIL, and both CBX7 and ANRIL are found at elevated levels in prostate cancer tissues. [Mol Cell]
The Phosphoinositide 3-Kinase Regulatory Subunit p85(Alpha) Can Exert Tumor Suppressor Properties through Negative Regulation of Growth Factor Signaling
Expression of Pik3r1 , the gene encoding p85, is decreased in human prostate, lung, ovarian, bladder, and liver cancers, consistent with the possibility that p85 has tumor suppressor properties. Researchers tested this hypothesis by studying mice with a liver-specific deletion of the Pik3r1 gene. [Cancer Res]
PSA Reduces Prostate Cancer Cell Motility by Stimulating TRPM8 Activity and Plasma Membrane Expression
In this study, researchers identified the well-known prostate cancer marker, prostate-specific antigen (PSA), as a physiological transient receptor potential melastatin 8 (TRPM8) agonist. [Oncogene]
Abrogation of De Novo Lipogenesis by Stearoyl-CoA Desaturase 1 Inhibition Interferes with Oncogenic Signaling and Blocks Prostate Cancer Progression in Mice
Researchers present recent results showing that lipid composition in human prostate cancer is characterized by an increased ratio of monounsaturated fatty acid (FA) to saturated FA, compared with normal prostate, and evidence the overexpression of the lipogenic enzyme stearoyl-CoA desaturase 1 in human prostate cancer. [Mol Cancer Ther]
Inhibition of Prostate Cancer Growth and Metastasis Using Small Interference RNA Specific for Minichromosome Complex Maintenance Component 7
In this study, researchers constructed a vector that constitutively expresses small interference RNA (siRNA) specific for MCM7. [Gene Ther]
Micronutrients Attenuate Progression of Prostate Cancer by Elevating the Endogenous Inhibitor of Angiogenesis, Platelet Factor-4
Researchers present unprecedented data whereby these combined micronutrients effectively promotes tumor dormancy in early prostate cancer, following initiation mutations that may drive the angiogenesis-dependent response of the tumor, by inducing platelet factor-4 expression and concentrating it at the tumor endothelium through enhanced platelet binding. [BMC Cancer]
CLINICAL RESEARCH
Surgery Confounds Biology: The Predictive Value of Stage, Grade and Prostate-Specific Antigen for Recurrence After Radical Prostatectomy as a Function of Surgeon Experience
Here researchers evaluate the association between several biological predictors and biochemical recurrence across varying surgical experience. [Int J Cancer]
Periostin is Up-Regulated in High Grade and High Stage Prostate Cancer
Here, researchers evaluated periostin expression in prostate cancer cells and peritumoural stroma immunohistochemically in two independent prostate cancer cohorts, including a training cohort (n=93) and a test cohort (n=325). [BMC Cancer]
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EVENTS
International Society for Stem Cell Research (ISSCR) 8th Annual Meeting
June 16-19, 2010
San Francisco, United States
21st Meeting of the European Association for Cancer Research (EACR)
June 26-29, 2010
Oslo, Norway
Translational Cancer Medicine 2010 - USA
July 11-14, 2010
San Francisco, United States
United Kingdom National Stem Cell Network (UKNSCN) Third Annual Scientific Conference
July 12-14, 2010
Nottingham, United Kingdom
2nd International Conference on Cellular and Molecular Bioengineering (ICCMB2)
August 2-4, 2010
Singapore City, Singapore
CHI's 5th Annual Immunotherapeutics and Vaccine Summit (ImVacS)
August 17-19, 2010
Cambridge, United States
2010 World Cancer Congress
August 18-21, 2010
Shenzhen, China
Joint Annual Meeting of the International Continence Society (ICS) and International Urogynecological Association (IUGA)
August 23-27, 2010
Toronto, Canada
Select Biosciences 3rd Annual Stem Cells Europe Conference
August 24-25, 2010
Edinburgh, Scotland
Select Biosciences 2nd Annual World Biobanking Summit
August 24-25, 2010
Edinburgh, Scotland
Select Biosciences Inaugural Cellular Therapy Summit
August 24-25, 2010
Edinburgh, Scotland
28th World Congress of Endourology and SWL
September 1-4, 2010
Chicago, United States
International Society for Cellular Therapy (ISCT) - Europe 2nd Regional Meeting
September 11-14, 2010
Belgirate, Italy
35th European Society for Medical Oncology (ESMO) Congress
October 8-12, 2010
Milan, Italy
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