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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)
LABORATORY RESEARCH
An Integrated Network of Androgen Receptor, Polycomb, and TMPRSS2-ERG Gene Fusions in Prostate Cancer Progression
These findings provide a working model in which TMPRSS2-ERG plays a critical role in cancer progression by disrupting lineage-specific differentiation of the prostate and potentiating the EZH2-mediated dedifferentiation program. [Cancer Cell]
Androgen Receptor Requires JunD as a Coactivator to Switch on an Oxidative Stress Generation Pathway in Prostate Cancer Cells
Here, researchers present coimmunoprecipitation and Gaussia luciferase reconstitution assay data that show that JunD forms a complex with androgen-activated androgen receptor in situ. [Cancer Res]
Epigenetic Mechanisms of Promigratory Chemokine CXCL14 Regulation in Human Prostate Cancer Cells
In this study, researchers investigated the mechanisms of loss of CXCL14 in prostate cancer cells. [Cancer Res]
Tissue Slice Grafts. An In Vivo Model of Human Prostate Androgen Signaling
Researchers developed a tissue slice graft model by implanting thin, precision-cut tissue slices derived from fresh primary prostatic adenocarcinomas under the renal capsule of immunodeficient mice. [Am J Pathol]
The Multikinase Inhibitor Sorafenib Induces Caspase-Dependent Apoptosis in PC-3 Prostate Cancer Cells
The present study investigated the effects of the multikinase inhibitor sorafenib on androgen-independent cancer cells viability and intracellular signaling. [Asian J Androl]
Antagonism of Estrogen-Mediated Cell Proliferation by Raloxifene in Prevention of Ageing-Related Prostatic Hyperplasia
Researchers evaluated the effect of estrogen antagonist, raloxifene, on the prevention and treatment of benign prostatic hyperplasia (BPH) by investigating its effect on the proliferation of two different prostate cell lines: a stromal cell line, WPMY-1, and a benign prostatic hyperplasia epithelial cell line, BPH-1. [Asian J Androl]
Osteoblasts Can Stimulate Prostate Cancer Growth and Transcriptionally Down-Regulate PSA Expression in Cell Line Models
The purpose of this study was to investigate the effect of bone environment on cellular proliferation, mature prostate-specific antigen (PSA) production and secretion, and PSA transcriptional regulation of prostate cancer cells. [Urol Oncol]
CLINICAL RESEARCH
Results From a Phase I Clinical Study of the Novel Ii-Key/HER-2/Neu(776-790) Hybrid Peptide Vaccine in Patients with Prostate Cancer
Researchers conducted the first phase I trial of an Ii-Key/HER-2/neu(776-790) hybrid peptide vaccine (AE37) with recombinant GM-CSF as adjuvant in patients with HER-2/neu+ prostate cancer. [Clin Cancer Res]
Clinical and Correlative Results of SWOG S0354: A Phase II Trial of CNTO328 (Siltuximab), a Monoclonal Antibody against Interleukin-6, in Chemotherapy-Pretreated Patients with Castration-Resistant Prostate Cancer
Researchers conducted a multicenter phase II study of CNTO328 (siltuximab) as second-line therapy for men with castration-resistant prostate cancer. [Clin Cancer Res]
Susceptibility Loci Associated with Prostate Cancer Progression and Mortality
Researchers investigated associations between 29 single nucleotide polymorphisms and biochemical recurrence, castration-resistant metastasis, and prostate cancer-specific survival. [Clin Cancer Res]
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POLICY NEWS
Personal Gene-Testing Companies Need U.S. Clearance, FDA Says
Gene-test kits that promise to tell consumers their risk of Alzheimer's disease, breast cancer and numerous illnesses must be approved by regulators whether the tests are sold online or in stores, a U.S. official said. [Food and Drug Administration, United States]
NIH Starts to Flesh out Drug Development Program
Lawmakers began discussing the details of a newly created drug development program at the National Institutes of Health (NIH). NIH Director Francis Collins told a Senate panel that he's eager to get started - once the program has a budget. [National Institutes of Health, United States]
Statement by HHS Secretary Kathleen Sebelius and NIH Director Francis Collins Regarding the President's Intent to Appoint Dr. Harold Varmus as Director of the National Institute of Cancer at the National Institutes of Health [National Institutes of Health, United States]
Enhancing Peer Review: Expectation for Service on NIH Peer Review and Advisory Groups (NOT-OD-10-089) [National Institutes of Health, United States]
Request for Information: Scientific and Regulatory Issues to be Explored at an Upcoming Pluripotent Stem Cell Workshop Involving NIH and FDA (NOT-NS-10-016) [National Institutes of Health, United States]
Drug Safety and Risk Management Advisory Committee; Notice of Meeting (Docket No. FDA-2010-N-0001) [Food and Drug Administration, United States]
Agency Information Collection Activities; Proposed Collection; Comment Request; Experimental Study of Patient Information Prototypes (Docket No. FDA-2010-N-0184) [Food and Drug Administration, United States]
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EVENTS
American Urological Association (AUA) 2010 Annual Meeting
May 29-June 3, 2010
San Francisco, United States
International Society for Stem Cell Research (ISSCR) 8th Annual Meeting
June 16-19, 2010
San Francisco, United States
21st Meeting of the European Association for Cancer Research (EACR)
June 26-29, 2010
Oslo, Norway
United Kingdom National Stem Cell Network (UKNSCN) Third Annual Scientific Conference
July 12-14, 2010
Nottingham, United Kingdom
2010 World Cancer Congress
August 18-21, 2010
Shenzhen, China
Joint Annual Meeting of the International Continence Society (ICS) and International Urogynecological Association (IUGA)
August 23-27, 2010
Toronto, Canada
28th World Congress of Endourology and SWL
September 1-4, 2010
Chicago, United States
35th European Society for Medical Oncology (ESMO) Congress
October 8-12, 2010
Milan, Italy
Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.
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