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CURRENT PUBLICATIONS
LABORATORY RESEARCH
Estrogen Receptor-Beta Activated Apoptosis in Benign Hyperplasia and Cancer of the Prostate is Androgen Independent and TNF(Alpha) Mediated
Data are indicative of the therapeutic potential of estrogen receptor-beta agonist for treatment of prostate cancer and/or benign prostatic hyperplasia with or without androgen withdrawal. [Proc Natl Acad Sci]
Role of Cationic Channel Transient Receptor Potential Vanilloid 2 (TRPV2) in Promoting Prostate Cancer Migration and Progression to Androgen Resistance
Researchers report that the nonselective cationic channel transient receptor potential vanilloid 2 is a distinctive feature of castration-resistant prostate cancer. [Cancer Res]
Variability in the Androgen Response of Prostate Epithelium to 5(Alpha)-Reductase Inhibition: Implications for Prostate Cancer Chemoprevention
Findings suggest that androgen receptor levels may predict the chemopreventive efficacy of 5(alpha)-reductase inhibitors. [Cancer Res]
Flavokawain B, a Kava Chalcone, Exhibits Robust Apoptotic Mechanisms on Androgen Receptor-Negative, Hormone-Refractory Prostate Cancer Cell Lines and Reduces Tumor Growth in a Preclinical Model
Resarchers have shown that flavokawain B, a kava chalcone, is about 4 to 12 fold more effective in reducing the cell viabilities of androgen receptor (AR)-negative, hormone-refractory prostate cancer cell lines DU145 and PC-3 than AR-positive, hormone-sensitive prostate cancer cell lines LAPC4 and LNCaP, with minimal effect on normal prostatic epithelial and stromal cells. [Int J Cancer]
Gossypol Induces Apoptosis by Activating p53 in Prostate Cancer Cells and Prostate Tumor-Initiating Cells
These studies show for the first time that gossypol treatment induces DNA damage and activates p53. [Mol Cancer Ther]
CCR9-Mediates PI3K/AKT Dependent Anti-Apoptotic Signals in Prostate Cancer Cells and Inhibition of CCR9-CCL25 Interaction Enhances the Cytotoxic Effects of Etoposide
Researchers show that CC chemokine receptor 9 and its natural ligand CCL25 interaction up regulates anti-apoptotic proteins and down regulate activation of caspase-3 in prostate cancer cells. [Int J Cancer]
Inhibition of Glycogen Synthase Kinase-3(Beta) Promotes Nuclear Export of the Androgen Receptor through a CRM1-Dependent Mechanism in Prostate Cancer Cell Lines
Results suggest that glycogen synthase kinase-3(beta) is an important element not only in androgen receptor (AR) stability but also significantly alters nuclear translocation of the AR, thereby modulating the androgenic response of human prostate cancer cells. [J Cell Biochem]
CLINICAL RESEARCH
Finasteride to Prevent Prostate Cancer: Should All Men or Only a High-Risk Subgroup Be Treated?
Researchers sought to determine whether prostate-specific antigen levels could identify a high-risk subgroup for which the benefits of finasteride treatment outweigh the potential harms. [J Clin Oncol]
Prognostic Parameters, Complications, and Oncologic and Functional Outcome of Salvage Radical Prostatectomy for Locally Recurrent Prostate Cancer after 21st-Century Radiotherapy
Investigators evaluated preoperative prognostic risk factors to predict organ-confined, locally recurrent prostate cancer after primary radiotherapy. [Eur Urol]
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EVENTS
SMi's Second Annual Stem Cells 2010
February 15-16, 2010
London, United Kingdom
Keystone Symposia: Stem Cell Differentiation and Dedifferentiation (B4)
February 15-20, 2010
Keystone, United States
5th Annual Stem Cell Summit
February 16, 2010
New York, United States
Third International Symposium on Focal Therapy and Imaging of Prostate and Kidney Cancer
February 24-27, 2010
Washington, DC, United States
The 3rd World Congress on Controversies in Urology (CURy)
February 25-28, 2010
Athens, Greece
2010 Genitourinary Cancers Symposium: Progress in Multidisciplinary Management
March 5-7, 2010
San Francisco, United States
American Association for Cancer Research (AACR) 101st Annual Meeting 2010
April 17-21, 2010
Washington, DC, United States
American Urological Association (AUA) Annual Meeting
May 29-June 2, 2010
San Francisco, United States
The 21st Meeting of the European Association for Cancer Research (EACR)
June 26-29, 2010
Oslo, Norway
2010 World Cancer Congress
August 18-21, 2010
Shenzhen, China
JOB OPPORTUNITIES
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Research & Development Scientist - Pancreatic Cell Biology (STEMCELL Technologies)
Research & Development Scientist - Endothelial Cell Biology (STEMCELL Technologies)
Research & Development Scientist - Epithelial Cell Biology (STEMCELL Technologies)
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