TOP STORIES

Scientists Identify Two Molecules That Affect Brain Plasticity in Mice
Researchers at the Stanford University School of Medicine have identified a set of molecular brakes that stabilize the developing brain's circuitry. [Stanford University Medical Center, Stanford]

SCIENCE NEWS

Emory Wins 1st Stem Cell Trial for ALS
Emory University will be the site of the first U.S. clinical trial that focuses on using stem cells to slow the progression of adults with Lou Gehrig's disease. [Neuralstem Inc., Rockville]

Researchers Use Gene Therapy to Slow Brain Disease
The brain disease X-linked adrenoleukodystrophy can be treated with a combination of gene therapy and blood stem cell therapy, new EU-funded research shows. [Universite Paris Descartes, Paris]

CURRENT PUBLICATIONS

Adult Generation of Glutamatergic Olfactory Bulb Interneurons
Examination of the progenitors of glutamatergic interneurons allowed the researchers to determine the sequential expression of transcription factors in these cells that are thought to be hallmarks of glutamatergic neurogenesis in the developing cerebral cortex and adult hippocampus. [Nat Neurosci]

Functional Excitatory GABA(A) Receptors Precede Ionotropic Glutamate Receptors in Radial Glia-like Neural Stem Cells
To investigate the expression profiles of the most important ionotropic neurotransmitter receptors, namely GABA(A) receptors, NMDA receptors, and AMPA receptors, quantitative RT-PCR, immunoblot analysis and patch clamp studies were performed in in vitro-generated neural stem cells. [Mol Cell Neurosci]

BS69 Undergoes SUMO Modification and Plays an Inhibitory Role in Muscle and Neuronal Differentiation
Researchers intensively investigated the localization of BS69 and its various truncated derivatives and found that: (a) BS69 forms an oligomer through its C-terminus and (b) both PHD and MYND domains are important for the localization of BS69. [Exp Cell Res]

Deciphering the Oligodendrogenic Program of Neural Progenitors: Cell Intrinsic and Extrinsic Regulators
The present review summarizes the current knowledge on the OPr, it implements the researchers findings on mesenchymal, stem cell-derived pro-oligodendroglial factors and on the role of p57/kip2 in oligodendroglial differentiation. [Stem Cells Dev]

Plasticity and Neural Stem Cells in the Enteric Nervous System
Scientists studied the presence of neural stem cells in the pre-, postnatal, and adult gut as a prerequisite for adaptation to changing conditions within the gut. [Anat Rec]

Adult Neural Stem Cells Expressing IL-10 Confer Potent Immunomodulation and Remyelination in Experimental Autoimmune Encephalitis
Researchers illustrated that adult neural stem cells (aNSCs) derived from the subventricular zone of the brain show modest therapeutic effects in EAE, an animal model of the chronic inflammatory neurodegenerative disease MS. [J. Clin. Invest]

INDUSTRY NEWS

University of Miami Biologist Receives NIH Grant to Create the First Map of Protein Interactions in Neurons
The University of Miami College of Arts and Sciences has been awarded a grant totaling $2.6 million distributed over two years, from the National Institute of Health, to launch a systematic survey of in situ protein-protein interaction networks, or "isPIN."

ReNeuron Awarded Two Grants Under Regenerative Medicine Funding Programme Established by UK Government
ReNeuron Group plc announces that it has been awarded two grants under the Government-backed Technology Strategy Board's Regenerative Medicine Programme.

Kyoto University Granted Patents for Stem Cell Production, Conversion Techniques
A patent for a set of techniques to convert artificially produced stem cells into nerve, muscle and other cell types has been granted to Kyoto University by the Japan Patent Office.

POLICY NEWS

Recovery Funds Advance Alzheimer's Disease Research
The National Institute on Aging, part of the National Institutes of Health, has targeted promising areas of research in granting the awards, such as new and ongoing studies to identify additional risk factor genes associated with Alzheimer's, improve diagnostic tools, find biomarkers, develop therapies, conduct clinical trials and explore preventive measures.

EVENTS

The Biology and Pathology of Tau and its Role in Tauopathies
January 7-8, 2010
Cambridge, United Kingdom

Keystone Symposia: Alzheimer's Disease Beyond Abeta (A4)
January 10-15, 2010
Copper Mountain, United States

CHI's Molecular Medicine Tri-Conference 2010
February 3-5, 2010
San Francisco, United States

Keystone Symposia: Stem Cell Differentiation and Dedifferentiation (B4)
February 15-20, 2010
Keystone, United States

2010 Canadian Neuroscience Meeting
May 15-18, 2010
Ottawa, Canada

ISSCR 8th Annual Meeting
June 16-19, 2010
San Francisco, United States

JOB OPPORTUNITIES

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Research & Development Scientist - Mesenchymal Cell Biology (STEMCELL Technologies)

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