Neural Cell News 3.37, September 16, 2009. Click here if you are unable to see images in this e-mail.


TOP STORIES

StemCells, Inc. to Initiate First Ever Neural Stem Cell Trial in Myelination Disorder
StemCells, Inc. announced recently that it will soon initiate a Phase I clinical trial to evaluate the therapeutic potential of StemCells' proprietary HuCNS-SC(R) product candidate to treat Pelizaeus-Merzbacher Disease. [StemCells Inc., Palo Alto]

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SCIENCE NEWS

STEMCELL Technologies Applauds Feeder-free Derivation of Human Induced Pluripotent Stem Cells
Using adipose cells as the starting cell population and mTeSR(TM)1, a defined medium that allows the expansion of human embryonic and induced pluripotent stem cells without the use of feeders, the researchers were able to fully reprogram cells to the pluripotent state. [STEMCELL Technologies, Vancouver]

Neurons Found to be Similar to Electoral College
A new study provides evidence that supports the "two-layer integration model," one of several competing models attempting to explain how neurons integrate synaptic inputs. [Northwestern University, Evanston]

Star-shaped Cells in the Brain Aid with Learning
Scientists have shown that certain cells in the brain, the astrocytes, actively influence the flow of information exchange by making nerve cells more efficient or increasing the number of cell contacts. [Max Planck Society, Munich]

Discovered Key Gene for the Formation of New Neurons
Scientists discovered a gene - called AP2gamma - crucial for the neural development of the visual cortex, in a discovery that can have implications for the therapeutics of neural regeneration. [Institute for Stem Cell Research, Munich]

New Neural Circuits Identified In The Retina
A new type of nerve cell, sensitive to approaching motion, has recently been identified in mice. [École Normale Supérieure, Paris]

Researchers Find Individual Cells Isolated from the Biological Clock can Keep Daily Time, but Are Unreliable
Researchers have demonstrated that individual cells isolated from the biological clock can keep daily time all by themselves, but get out of synch and capriciously quit or start oscillating again. [Washington University in St.Louis, St.Louis]

Robot with a Biological Brain: New Research Provides Insights into How the Brain Works
British scientists are on track to develop a new robot which they claim will be controlled by a blob of human brain cells. [University of Reading, Reading]

Sculpting Cells with Light
The power to manipulate cells at will comes courtesy of a new genetically encoded switch that lets researchers use light to control a cell's shape and movement. [Howard Hughes Medical Institute, Chevy Chase]

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.

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CURRENT PUBLICATIONS

Intermediate Neuronal Progenitors (Basal Progenitors) Produce Pyramidal-Projection Neurons for All Layers of Cerebral Cortex
Here, the researchers investigated the cellular properties and neurogenic output of basal progenitors, also called intermediate neuronal progenitors. [Cerebal Cortex]

MicroRNA-125b Promotes Neuronal Differentiation in Human Cells by Repressing Multiple Targets
The investigators report here the expression profile of miRNAs during neuronal differentiation in the human neuroblastoma cell line SH-SY5Y. [Mol Cell Biol]

Myosin II is Required for Interkinetic Nuclear Migration of Neural Progenitors
In this study, scientists have established a culture system of mouse embryonic telencephalon that reproduces cortical development, and have applied it to explore a role of actomyosin in interkinetic nuclear migration. [Proc Natl Acad Sci USA]

Human Neural Stem Cells Overexpressing Glial Cell Line-derived Neurotrophic Factor in Experimental Cerebral Hemorrhage
In this study, a stable human NSC line overexpressing GDNF (F3.GDNF) was transplanted next to the intracerebral hemorrhage lesion site and a possible therapeutic effect was investigated. [Gene Therapy]

Polycomb Limits the Neurogenic Competence of Neural Precursor Cells to Promote Astrogenic Fate Transition
Here, the researchers show that the polycomb group complex restricts neurogenic competence of neural precursor cells and promotes the transition of NPC fate from neurogenic to astrogenic. [Neuron]

Sox2 Roles in Neural Stem Cells
These studies uncovered a requirement for Sox2 in the maintenance of neural stem cells, as well as a downstream role in the differentiation of specific neuron sub-types. [Int J Biochem Cell Biol]

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INDUSTRY NEWS

Connexon Creative Launches Mesenchymal Cell News
Mesenchymal Cell News is a free, weekly e-newsletter that keeps the mesenchymal cell community informed by providing the latest news from all areas of the field, including its science, policy, and business.

ReNeuron Signs Manufacturing Contract for Second-generation CTX Stem Cell Product
ReNeuron Group plc recently announced that it has signed a contract with Angel Biotechnology Holdings plc, under which Angel will manufacture clinical-grade lots of a second-generation formulation of ReNeuron's lead CTX stem cell line, for subsequent pre-clinical and clinical applications.

Edward Announces New Neurosciences Institute in Partnership with Northwestern Medical Faculty Foundation
Edward Hospital announced recently that it has established the Edward Neurosciences Institute in affiliation with the Northwestern Medical Faculty Foundation.

Neuralstem Receives Notice of Patent Allowance
Neuralstem, Inc. recently announced that it has received notice of allowance from the United States Patent and Trademark Office for its patent entitled "Transplantation of Human Neural Cells for Treatment of Neurodegenerative Conditions".



POLICY NEWS

Legislature Approves Stem Cell and Biotechnology Education Bill
A bill to help California develop a homegrown workforce for the state's stem cell and biotechnology industries cleared its final hurdle in the legislature recently with Senate approval of amendments the Assembly adopted Tuesday.



EVENTS

The 2nd Annual Maryland Stem Cell Research Symposium
September 21 2009
Baltimore, United States

World Stem Cell Summit 2009
September 23-25, 2009
Baltimore, United States

Neuroscience 2009
October 17-21, 2009
Chicago, United States

Alzheimer's Disease Beyond Abeta
January 10-15, 2010
Copper Mountain, United States

Molecular Medicine Tri-Conference 2010
February 3-5, 2010
San Francisco, United States

ISSCR 8th Annual Meeting
June 16-19, 2010
San Francisco, United States


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