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TOP STORIES

From Nerve Roots to Plant Roots - Researchers are Gaining Unexpected Insights into Hereditary Spastic Paraplegia
A new study from the National Institutes of Health and Harvard Medical School suggests that neurons and plant root cells may grow using a similar mechanism. [National Institute of Neurological Disorders and Stroke, Bethesda]

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SCIENCE NEWS

UC Irvine Discovers New Alzheimer's Gene
A UC Irvine study has found that a gene called TOMM40 appears twice as often in people with Alzheimer's disease than in those without it. [University of California, Irvine, Irvine]

Tension in Axons is Essential for Synaptic Signaling
Every time a neuron sends a signal - to move a muscle or form a memory, for example - tiny membrane-bound compartments, called vesicles, dump neurotransmitters into the synapse between the cells. [University of Illinois, Chicago]

"Jumping Genes" Create Diversity in Human Brain Cells, Offering Clues to Evolutionary and Neurological Disease
Rather than sticking to a single DNA script, human brain cells harbor astonishing genomic variability, according to scientists at the Salk Institute for Biological Studies. [Salk Institute for Biological Studies, San Diego]

Researcher Discovers Genetic Circuit that Regulates Behavior of Stem Cells
European researchers have discovered that that embryonic stem cells are in a state of biochemical repose, static, awaiting a signal that causes them to differentiate is not correct, and that in fact the state of pluripotentiality in stem cells is anything but static. [Universitat Politecnica de Catalunya, Terrassa]

VIDEO: Researchers Identify Phosphorylated Signaling Proteins in Human Embryonic Stem Cells
Investigators have made the first comparative, large-scale phosphoproteomic analysis of human embryonic stem cells and their differentiated derivatives. [Burnham Institute for Medical Research , Burnham]

Yale Researchers Find Key to Keeping Cells in Shape
Yale University researchers have discovered how a protein within most cell membranes helps maintain normal cell size, a breakthrough in basic biology that has implications for a variety of diseases such as sickle cell anemia and disorders of the nervous system. [Yale University, Yale]

Two Lines Account for Most Human Embryonic Stem Cell Research
For the past eight years, scientists who wanted to use federal funds for research on human embryonic stem cells had to restrict their studies to 21 cell lines approved by the National Institutes of Health. But an analysis by a researcher at the Stanford University School of Medicine suggests that only two of those lines have been used routinely. [Stanford School of Medicine, Stanford]

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.

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CURRENT PUBLICATIONS

The Death Receptor CD95 Activates Adult Neural Stem Cells for Working Memory Formation and Brain Repair
This report show that in neural stem cells, stimulation of the death receptor CD95 does not trigger apoptosis but unexpectedly leads to increased stem cell survival and neuronal specification. [Cell, Stem Cell]

Collagen Nerve Conduits Promote Enhanced Axonal Regeneration, Schwann Cell Association, and Neovascularization Compared to Silicone Conduits
The researchers in this report examined peripheral nerve regeneration in both silicone- and collagen-based nerve conduits in both 5- and 10-mm-injury gaps in rat sciatic nerves. [Tissue Engineering Part A]

Cholesterol Involvement in the Pathogenesis of Neurodegenerative Diseases
Here, recent advances in terms of the role of cholesterol in healthy brain and molecular mechanisms of cholesterol involvement in Alzheimer's disease, Parkinson's disease and Niemann-Pick disease type C diseases are reviewed. [Molecular and Cellular Neuroscience]

5-HT4 Receptor-Mediated Neuroprotection and Neurogenesis in the Enteric Nervous System of Adult Mice
This study tested the hypothesis that stimulation of the 5-HT4 receptor promotes enteric neuron survival and/or neurogenesis in mice models. [The Journal of Neuroscience]

The Neural Stem Cell Line CTX0E03 Promotes Behavioral Recovery and Endogenous Neurogenesis After Experimental Stroke in a Dose-Dependent Fashion
This study investigated behavioral recovery in rats following implanting increasing doses of CTX0E03 cells into the putamen ipsilateral to the stroke damage. [Neurorehabilitation and Neural Repair]



INDUSTRY NEWS

Connexon Creative Launches Cord Blood News
Cord Blood News is a weekly e-newsletter that keeps members of the cord blood community informed by providing the latest news from all areas of the field, including its science, research, policy, and business.

University Hospitals Case Medical Center Selects STEMSOFT Software for Entire BMT Program
STEMSOFT Software Inc, the leading provider of software solutions for cell therapy transplant programs, is pleased to announce the licensing of STEMSOFT's complete suite of applications to the University Hospitals Case Medical Center. [STEMSOFT, Vancouver]

Opexa Announces Stem Cell Agreement with Novartis
Opexa Therapeutics, Inc recently announced that it has entered into an exclusive agreement with Novartis for the further development of Opexa's novel stem cell technology. [Opexa Therapeutics, Inc, The Woodlands]

DARA BioSciences, Inc. and America Stem Cell, Inc. Collaborate On Stem Cell Research
DARA BioSciences, Inc. announced recently that the Company is collaborating with America Stem Cell to expand on observations from recent preclinical studies showing that dipeptidylpeptidase inhibitors improve the efficiency of hematopoietic stem cell transplants. [DARA BioSciences, Raleigh]

Athersys Looking for Commercial Partners to Advance Stem Cell, Drug Therapies
Biopharmaceutical company Athersys Inc. is looking for commercial partners to help it develop and test its stem cell and drug therapies aimed at treating a variety of health problems. [Athersys Inc., Cleveland]

Millipore Licenses Novel Stem Cell Technology from Boston University
Boston University and Millipore Corporation recently announced a licensing agreement for a highly efficient method for creating induced Pluripotent Stem cells derived from mouse fibroblasts by using a single virus vector instead of multiple viruses in the reprogramming process. [Millipore, Billerica]

Pluristem's Award from the Israeli Office of the Chief Scientist Increased to $2.3 Million
Pluristem Therapeutics Inc. will receive a total of $2.3 million in funding for its stem cell programs from the Ministry of Industry, Trade and Labor of Israel; an increase from the previously announced amount of $1.9 million. [Pluristem, Haifa]

BMTbase(TM) 4 Beta Version Released
Completely redesigned from the ground up using .NET technology, version 4 is a browser-based application allowing for easier user access, deployment and more robust database management and security. (STEMSOFT, Vancouver)



POLICY NEWS

Two Lines Account for Most Human Embryonic Stem Cell Research
For the past eight years, scientists who wanted to use federal funds for research on human embryonic stem cells had to restrict their studies to 21 cell lines approved by the National Institutes of Health. But an analysis by a researcher at the Stanford University School of Medicine suggests that only two of those lines have been used routinely. [Stanford School of Medicine, Stanford]

Legislature to Duke It Out Over Stem Cell Regulations
Opponents of embryonic stem cell research in Michigan have mobilized to push for proposals requiring in-vitro fertilization patients to sign a consent form that addresses issues such as potential excess embryos, costs to store leftover embryos and a statement on the prohibition of accepting anything valuable in exchange for frozen embryos.



EVENTS

World Stem Cell Summit 2009
September 23-25, 2009
Baltimore, United States

TERMIS 2nd World Congress 2009
August 31 - September 3, 2009
Seoul, South Korea

Neuroscience 2009
October 17-21, 2009
Chicago, United States

Alzheimer's Disease Beyond Abeta
January 10-15, 2010
Copper Mountain, United States

Molecular Medicine Tri-Conference 2010
February 3-5, 2010
San Francisco, United States

ISSCR 8th Annual Meeting
June 16-19, 2010
San Francisco, United States


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