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TOP STORIES

Landmark Stem Cells Trial Yields Positive Results
The Phase I trial of HuCNS-SC (purified human neural stem cells) conducted at OHSU Doernbecher Children's Hospital included six children with advanced stages of infantile and late-infantile neuronal ceroid lipofuscinosis, often referred to as Batten disease.

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SCIENCE

Australian Research Shows Brain Cells Make Clever Connections
University of Queensland research has revealed that growing nerve fibers may navigate by using a clever mathematical trick.

Newly Found Peptide Offers Hope of Early Test and Better Treatment
Researchers in Japan have detected a peptide in cerebrospinal fluid that can show whether a person is developing Alzheimer's disease.

Popular Alzheimer's Theory May be False Trail
Researchers discovered that inflammation of microglia does not appear to be associated with dementia in Alzheimer's disease.

NIH Researchers Discover How Prion Protein Damages Brain Cells
Scientists at the National Institutes of Health have gained a major insight into how the rogue protein responsible for mad cow disease and related neurological illnesses destroys healthy brain tissue.

Cold Spring Harbor Laboratory Researchers Unravel How a Protein Helps Nerve Cells Recycle Neurotransmitter-containing Vesicles
Researchers at Cold Spring Harbor Laboratory report that the recycling of vesicles, is controlled by a protein whose lack of function has been known to cause a brain developmental disorder called X-linked mental retardation.

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ABSTRACTS

GABA's Control of Stem and Cancer Cell Proliferation in Adult Neural and Peripheral Niches
In this study, the researchers discuss GABA's presence as a near-universal signal that may be altered in tumor cells resulting in modified mitotic activity. (Physiology)

Circumventricular Organs: A Novel Site of Neural Stem Cells in the Adult Brain
In the present study, the researchers show that in adult rat and mouse, the circumventricular organs are rich in nestin+, GFAP+, vimentin+ cells which express Sox2 and the cell cycle-regulating protein Ki67. (Molecular and Cellular Neuroscience)

Cytokine-induced SOCS Expression is Inhibited by cAMP Analogue: Impact on Regeneration in Injured Retina
This study set out to determine whether ciliary neurotrophic factor injections increase retinal suppressor of cytokine signaling expression and whether any changes are attenuated by co-injection with CPT-cAMP. (Molecular and Cellular Neuroscience)

Human Embryonic Stem Cell-derived Neuronal Cells Form Spontaneously Active Neuronal Networks in Vitro
To study the potential functionality of hESC-derived neurons, the researchers cultured and monitored the development of hESC-derived neuronal networks on microelectrode arrays. (Experimental Neurology)

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INDUSTRY

Connexon Creative Launches Mammary Cell News
Mammary Cell News is a weekly e-newsletter that keeps members of the mammary cell community informed by providing the latest news from all areas of the field, including its science, research and business.

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NIH Funds Einstein Center to Target HIV-related Brain Disease
The National Institute on Drug Abuse of the National Institutes of Health has awarded a three-year, $3-million grant to Albert Einstein College of Medicine of Yeshiva University to establish a research center to study the neurological complications that afflict people infected with HIV, the virus that causes AIDS.

ReNeuron Signs Manufacturing Contract to Provide Stem Cells for Stroke Clinical Trial
ReNeuron Group plc recently announced that it has signed a contract with Angel Biotechnology Holdings plc, under which Angel will manufacture clinical-grade ReN001 stem cell lots for ReNeuron's Phase I clinical trial with its ReN001 therapy in disabled stroke patients.

ThermoGenesis Nabs NIH Grant for Stem Cell Delivery
ThermoGenesis Corp. said recently it has received a grant from the National Institute of Health to study and develop biomaterials that can be used to deploy placental stem cells in bone repair and regenerative medicine applications.

Vitro Receives Adult Stem Cell Patent from the United States Patent and Trademark Office
Vitro Diagnostics, Inc., dba Vitro Biopharma, announced that it has been awarded United States Patent number 7,527,971 entitled, "Generation and Differentiation of Adult Stem Cells."



POLICY

Despite Odds, Cities Race to Bet on Biotech
At a recent global biotech convention in Atlanta, 27 states, including Hawaii and Oklahoma, paid as much as $100,000 each to entice companies on the exhibition floor. All this for a highly risky industry that has turned a profit only one year in the past four decades.

Bob Klein to Leave CIRM Chairman Job
Bob Klein, the architect of California's $3 billion stem cell research funding program, will not seek a new term as chairman of the agency.

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