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TOP STORIES

University of Buffalo Scientists Develop Novel Method to Stimulate Growth of New Neurons in Adult Brain
University at Buffalo researchers have identified a new mechanism that plays a central role in adult brain stem cell development and prompts brain stem cells to differentiate into neurons.

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SPECIAL FEATURE

VIDEO: Isolate Specific Cell Types from Human Blood



SCIENCE

Cerebral Neurons Assist Adjacent Neurons
Scientists at the Ruhr University Bochum were able to reveal neuron rewiring with a new method that makes use of voltage-sensitive dyes that light up if cells send or receive electric signals.

UnMASCing Diseases of the Brain
Scientists at the Wellcome Trust Sanger Institute have discovered a set of brain proteins responsible for some of the most common and devastating brain diseases.

Special Protein Helps Maintain an Efficient Brain
The instruction manual for maintaining an efficient brain may soon include a section on synaptotagmin-IV (Syt-IV), a protein known to influence learning and memory, thanks to a study by UW-Madison researchers.

New Tool Isolates RNA Within Specific Cells
University of Oregon biologists provide quick, precise view of cell development and gene expression.

Identification of a Key Molecular Pathway Required for Brain Neural Circuit Formation
The researchers recent work showed that Sonic Hedgehog (Shh) exerts its molecular attractive effect through a group of molecules called Src family kinases (SFKs) that, until now, were not known to be linked to Shh function.

One Size Does Not Fit All: A New Look at Therapies
A new study by researchers at the Montreal Neurological Institute, McGill University, demonstrates that statin therapy in mice inhibits myelin repair or remyelination in the central nervous system.

McGill and Lady Davis Institute Findings Help Pinpoint Molecular Cause of the Disease
Researchers report that the addition of a single phosphate to an amino acid in a key brain protein is a principal cause of Alzheimer's.

Nervous System May be Culprit in Deadly Muscle Disease
Researchers have discovered that signals from the brain to the diaphragm - the muscle that controls breathing - are too weak to initiate healthy respiration in mouse models of the disease.

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.

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ABSTRACTS

Neural Induction in Mouse Embryonic Stem Cells by Co-culturing with Chicken Somites
This study reports the influence of the co-culture of alginate bead-encapsulated somites isolated from chick embryos on neural differentiation in mouse embryonic stem cells-derived embryoid bodies. [Stem Cells and Development]

Peptides Modeled After the a-domain of Metallothionein Induce Neurite Outgrowth and Promote Survival of Cerebellar Granule Neurons
The present study identified two MT a-domain-derived peptide sequences termed EmtinAn and EmtinAc, as potent stimulators of neuronal differentiation and survival of primary neurons. [European Journal of Cell Biology]

Differential Requirement for Nucleostemin in Embryonic Stem Cell and Neural Stem Cell Viability
The molecular basis of nucleostemin function, one of proteins that are enriched in many types of stem cells, in early mouse embryos remains largely unknown, and the role of nucleostemin in tissue stem cells has not been examined by gene targeting analyses due to the early embryonic lethality of nucleostemin null animals. [Stem Cells]

Efficient Genetic Reprogramming of Unmodified Somatic Neural Progenitors Uncovers the Essential Requirement of Oct4 and Klf4
Retroviral transduction of the factors Oct4, Sox2, Klf4, and c-Myc successfully reverted NSCs to a pluripotent embryonic stem cell-like state with a 2-fold efficiency increase, faster kinetic, and with a lower number of viral integrations. [Stem Cells and Development]

Polysialic Acid Glycomimetics Promote Myelination and Functional Recovery after Peripheral Nerve Injury in Mice
This paper investigated whether Polysialic acid can improve functional recovery after peripheral nerve lesion in adult mice. [Brain]

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INDUSTRY

Victoria, Australia and California Form Stem Cell Alliance
Victorian Innovation Minister Gavin Jennings announced four collaborative grants between Victorian and Californian teams.

UC Davis Opens Horse Stem Cell Lab
The Regenerative Medicine Laboratory at the William R. Pritchard Veterinary Medical Teaching Hospital allows for processing, culturing and storing stem cells for horses.

Oklahoma Stem Cell Research Gets $5.5M
The Tobacco Settlement Endowment Trust board voted Monday to contribute $5.5 million to adult stem cell research.

Novocell Awarded Patent for Innovative Stem Cell Therapy for Diabetes
Novocell, Inc. recently announced that it has received U.S. Patent No. 7,534,608 with method claims covering the Company's innovative stem cell therapy for the production of functional pancreatic, insulin producing cells from human embryonic stem cells.

Stem Cell Therapeutics Announces Issuance of Additional US Patent for Use of Prolactin
Stem Cell Therapeutics Corp. has been issued United States Patent No. 7,534,765 covering methods of using of prolactin for enhancing the formation of oligodendendrocytes in vivo.

Stem Cell Therapeutics Corp. Releases Encouraging Clinical Results and Provides Corporate Update
Stem Cell Therapeutics has decided to commence the modified Phase IIb REGENESIS clinical stroke trial as soon as possible, with the goal of completing patient enrollment by the end of 2009.

£4m Grant for Stem Cell Research
A £4 million British Government grant has been awarded to scientists conducting research into stem cell treatments for broken bones.



POLICY

Ac"cell"erate Your Research with the NIH Stimulus Package and Robosep(R)

Notice of Change in the Receipt Date for PAR-07-456, NINDS Diversity Research Education Grants in Neuroscience (R25)

New Democratic Coalition Proposes Independent Panel To Oversee Comparative Effectiveness Research
Members of the moderate New Democratic Coalition on Tuesday proposed legislation (HR 2502) that would establish a non-governmental, independent office to oversee research efforts to compare the effectiveness of medical treatments.

New Rules on Stem Cells Threaten Current Research
Many proponents of federal stem cell funding have concluded that the plan could have the opposite effect, putting off-limits for federal support much of the research underway, including work that the Bush administration endorsed.

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