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ESC_IS1

ReNeuron Gains UK Regulatory Approval to Start Ground-breaking Clinical Trial with Stem Cell Therapy for Stroke
ReNeuron Group plc recently announced that it has received approval from the UK Medicines and Healthcare Products Regulatory Agency to commence a first-in-man clinical trial for the treatment of patients who have been left disabled by an ischaemic stroke, the most common form of the condition.




SCIENCE

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Study Shows How Defective DNA Repair Triggers Two Neurological Diseases
Scientists at St. Jude Children's Research Hospital have teased apart the biological details distinguishing two related neurological diseases-ataxia telangiectasia-like disease and Nijmegen breakage syndrome.

Institut Pasteur Researchers Demonstrate Microscopic, Deep Brain Imaging in Freely Moving Mice, Detecting GFP Molecule
Institut Pasteur researchers have demonstrated microscopic, real-time imaging of the deepest regions of the brain in a freely moving mouse, using it to analyze the expression of Green Fluorescent Protein.

Biologists at Tufts University Discover Link Between CGG Repeats and DNA Damage
Scientists at Tufts University have found that repetitive DNA sequences are associated with hereditary neurological disorders such as fragile X syndrome and FRAXE mental impairment.

Neurons Show Sex-dependent Changes During Starvation
Researchers found that nutrient deprivation caused Male neurons to wither up and died, while female neurons did their best to conserve energy and stay alive.




ABSTRACTS

Guided Growth of Neurons and Glia Using Microfabricated Patterns of Parylene-C on a SiO2 Background
In this study a highly consistent, straightforward and cost effective cell patterning scheme has been developed for the patterning of glia and neurons.

Dll1 and Dll4 Function Sequentially in the Retina and pV2 Domain of the Spinal Cord to Regulate Neurogenesis and Create Cell Diversity
This paper shows that two Delta-like genes, Dll1 and Dll4, are sequentially expressed in differentiating neurons of the embryonic mouse retina and spinal cord's pV2 domain, with Dll1 starting to be expressed before Dll4.

Reptin52 Expression During in vitro Neural Differentiation of Human Embryonic Stem Cells
The researchers analyzed hESC and hESC-derived neural stem cell nuclear extracts revealing an increased expression of Reptin52 in neurosphere nuclei.

Influence of Terminal Nerve Branch Size on Motor Neuron Regeneration Accuracy
The present studies use the mouse femoral nerve as a model system to examine factors that influence such motor neuron regeneration accuracy.




INDUSTRY

Cellartis, WARF Sign License Agreement for Human Embryonic Stem Cells
Cellartis AB and the Wisconsin Alumni Research Foundation announced recently that they have signed a license for hES patents that enables Cellartis to commercialize undifferentiated hES cell products in the U.S.

VistaGen and Capsant Sign Strategic Stem Cell Technology Commercialization Agreement
VistaGen and Capsant have signed a strategic commercialization agreement under which the companies will combine their leading-edge stem cell biology and 3D cell culture platforms, respectively, to advance their mutual business interests worldwide.

California Panel Warns Stem Cell Agency Board Member
A California ethics panel has chided a member of the state's stem cell agency board for trying to influence funding for a La Jolla research institute he leads.




POLICY

Japanese Ministry Set to Boost Stem Cell Patent Support
The Education, Science and Technology Ministry has decided to expand support for universities and research institutions bidding to patent technologies and ideas used in their studies on induced pluripotent stem cells, officials said.

MPs to Investigate Stem Cell Funding Row
The two research councils that have turned down requests to fund stem cell studies using human-animal "hybrid" embryos are to be questioned by MPs on both sides of the House of Commons to explain why they have refused to issue the grants.

VIDEO: White House Stem Cell Shift Expected
A major shift in White House policy on stem cell research is expected when Barack Obama takes office.



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