TOP STORIES

Bone Graft Grown in Exact Shape of Complex Skull-Jaw Joint
Technique could be a preferred substitute for replacing missing or damaged bones with titanium, donated bones or those harvested from elsewhere in a patient's body. [Columbia University, New York]

SCIENCE NEWS

Webinar: Feeder-independent growth of hESCs & hiPSCs using TeSR™2

VIDEO: Introducing TeSR2 medium for feeder-free, animal protein-free culture of human ESCs and iPSCs

Major Improvements Made In Engineering Heart Repair Patches from Stem Cells
Researchers have succeeded in engineering human tissue patches free of some problems that have stymied stem-cell repair for damaged hearts. [University of Washington, Seattle]

Mesenchymal Gaucho Homing on the Range
Scientists demonstrate that lysosomal glucocerebrosidase deficiency in GD1 bone marrow MSCs is associated with increased cellular glucosylceramide and up-regulation of inflammatory mediators that may promote bone mineral loss and hematologic malignancy. [Blood]

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CURRENT PUBLICATIONS

Regeneration Next: Toward Heart Stem Cell Therapeutics
This study examines experimental paradigms to address the critical steps in the transition from stem cell biology to regenerative medicine, utilizing cardiovascular disease as a case study. [Cell Stem Cell]

Adult Rat Mesenchymal Stem Cells Differentiate into Neuronal-like phenotype and Express a Variety of Neuro-regulatory Molecules in Vitro
This paper re-evaluates the phenomenon of neuronal trans-differentiation of marrow stromal stem cells and compares the expression levels of neurotrophins in rMSCs and neuronal-like phenotypes derived from rMSCs. [Neurosci Res]

Non-viral Gene Delivery of DNA Polyplexed with Nanoparticles Transfected into Human Mesenchymal Stem Cells
In this study, a non-viral gene delivery system using nanoparticles was designed, with emphasis placed on the ability of the system to mediate high levels of gene expression into stem cells. [Biomaterials]

Requirement of IFN-[gamma]-Mediated Indoleamine 2,3-Dioxygenase Expression in the Modulation of Lymphocyte Proliferation by Human Adipose-Derived Stem Cells
This study reports that hASCs inhibit peripheral blood mononuclear cells, and CD4+ and CD8+ T cell proliferation in both cell-cell contact and transwell conditions, which is accompanied by a reduction of proinflammatory cytokines. [Tissue Eng Part A]

INDUSTRY NEWS

STEMCELL Technologies Inc. Introduces MethoCult(R) Express for Cord Blood Banks and Transplant Centers
STEMCELL Technologies Inc., announces the launch of MethoCult(R) Express, an innovative methylcellulose-based medium specifically formulated to allow enumeration of total colony-forming cells after only 7 days of culture. With this new medium, reliable information on hematopoietic progenitor cell numbers in cord blood can be obtained much earlier than with standard 14-day assays.

STEMCELL Technologies Inc. Announces Direct Distribution to Spain
STEMCELL Technologies Inc., a leader in specialty cell culture media, cell separation products and ancillary reagents for life science research, is pleased to announce that they are now selling directly to customers in Spain.

Isolagen, Inc. Reorganizes as Fibrocell Science, Inc.
Isolagen, Inc. has reorganized and emerged from bankruptcy as Fibrocell Science, Inc., a biotechnology company focused on developing regenerative fibroblast cells for aesthetic, medical and scientific applications.

Stem Cell Therapy International, Inc. Announces U.S. Patent Awarded for Isolation of Stem Cells for Therapy
Stem Cell Therapy International, Inc. announced that its subsidiary has been awarded a U.S. Patent entitled "Method of Isolating and Culturing Mesenchymal Stem Cell Derived from Cryopreserved Umbilical Cord Blood."

NIH Grantees Win 2009 Nobel Prize in Physiology or Medicine for Telomere Research
The three researchers are honored for discovering how telomeres, through the enzyme telomerase, protect chromosomes against degradation.

Mass. Biotech Firms Urged to Remain Independent
Industry leaders warned that the old model of forming a biotech company, shepherding a drug through development and years of clinical trials, and then selling the company to a pharmaceutical buyer may be played out.

POLICY NEWS

A Clear Line on Stem Cells
The Stem Cell Research Enhancement Act of 2009 will be introduced shortly codify Mr. Obama's executive order permitting federal funding of such research within guidelines established by the NIH.

NHLBI Awards $170 Million to Fund Stem Cell Research
The National Heart, Lung, and Blood Institute, one of the National Institutes of Health, has awarded $170 million to be paid over seven years to 18 teams of research scientists to develop the high-potential field of stem and progenitor cell tools and therapies.

NIH Awards Grants to Examine Factors Influencing Women's Careers in Science
The National Institutes of Health announced today that it will fund 14 grants focusing on factors that influence the careers of women in biomedical and behavioral science and engineering.

MBRS Research Initiative for Scientific Enhancement (RISE) (R25)

Russia Stem Cell Firm Sees Post-IPO Market Cap at $28m
Russia's Stem Cell Institute said on Wednesday it plans to raise up to 165 million rubles ($5.53 million) in what will be the country's first initial public offering since the financial crisis erupted last year.

EVENTS

Mesenchymal Stem Cell Conference 2009
November 12-14, 2009, Austin, TX, United States

Molecular Tri Conference & The Stem Cell Meeting
February 2-5, 2010, San Francisco, CA, United States

Blood and Marrow Transplantation
February 24-28, 2010, Orlando, FL, United States

World Congress Regenerative Medicine
March 12-14, 2010, Bangkok, Thailand

The European Group for Blood & Marrow Transplantation Annual Meeting
March 21-24, 2010, Vienna, Austria

9th Transgenic Technology Meeting
March 22-24, 2010, Berlin, Germany

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