CURRENT PUBLICATIONS

Negative Regulation of MyD88-Dependent Signaling by IL-10 in Dendritic Cells
Researchers describe a regulatory mechanism by which IL-10-mediated protein degradation contributes to the inhibition of inflammatory cytokine production and endotoxin tolerance in DC. [PNAS]

Interleukin 10 Acts on Regulatory T Cells to Maintain Expression of the Transcription Factor Foxp3 and Suppressive Function in Mice with Colitis
Data indicate that IL-10 released from myeloid cells acts in a paracrine manner on Treg cells to maintain Foxp3 expression. [Nat Immunol]

Thymic Indoleamine 2,3-Dioxygenase Positive Eosinophils in Young Children. Potential Role In Maturation Of The Naive Immune System
Results suggest that functional thymic IDO+ eosinophils during human infant life may have an immunomodulatory role in Th2 immune responses. [Am J Pathol]

PPAR-Delta Senses and Orchestrates Clearance of Apoptotic Cells to Promote Tolerance
Peroxisome proliferator-activated receptor-Delta (PPAR-Delta) has a pivotal role in orchestrating the timely disposal of apoptotic cells by macrophages, ensuring that tolerance to self is maintained. [Nat Med]

The Regulatory T-Cell Response During Acute Retroviral Infection is Locally Defined and Controls the Magnitude and Duration of the Virus-Specific Cytotoxic T-Cell Response
Results demonstrate the important role of Treg in controlling acute retrovirus-specific CD8+ T-cell responses, and suggest that temporary manipulation of Treg might be a possible therapeutic approach in chronic infectious diseases. [Blood]

The Key Role of Segmented Filamentous Bacteria in the Coordinated Maturation of Gut Helper T Cell Responses
Systematic analysis of gnotobiotic mice indicated that colonization by a whole mouse microbiota orchestrated a broad spectrum of proinflammatory T helper 1 (Th1), Th17, and regulatory T cell responses whereas most tested complex microbiota and individual bacteria failed to efficiently stimulate intestinal T cell responses. [Immunity]

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