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Embryonic Stem Cell News 4.47, November 25, 2009. Click here if you are unable to see images in this e-mail.

In this issue: Science News | Current Publications | Industry News | Policy News | Events

New Research Suggests Stem Cells from Amniotic Fluid May be More Versatile than Originally Thought
Reporting in Oncogene, researchers show that amnion stem cells can form three-dimensional aggregates of cells known as embryoid bodies (EBs). [Wake Forest Institute for Regenerative Medicine, Winston-Salem]

SCIENCE NEWS

Is Hepatic Differentiation of Embryonic Stem Cells Induced by Valproic Acid and Cytokines?
Results showed that Valproic acid (VPA), a histone deacetylase inhibitor, can direct the hepatic specification of ES cells and largely participates in the differentiation of ES cells into hepatic progenitors. [Zhejiang University, Hangzhou]

Stem Cells Could Create New Skin to Help Burns Victims
French researchers say they have found a way of using human embryonic stem cells to create new skin which could help serious burns victims. [Institute for Stem Cell Therapy and Exploration of Monogenic Diseases, Evry]

Advanced Cell Technology Files IND With FDA For First Human Clinical Trial Using Embryonic Stem Cells to Treat Eye Disease
Advanced Cell Technology, Inc. announced today that it filed an Investigational New Drug (IND) Application with the US Food and Drug Administration (FDA) to initiate a Phase I/II multicenter study using embryonic stem cell derived retinal cells to treat patients with Stargardt's Macular Dystrophy (SMD). [Advanced Cell Technology, Inc., Worcester]

CURRENT PUBLICATIONS

Embryoid Body Formation of Human Amniotic Fluid Stem Cells Depends on mTOR
The formation of three-dimensional aggregates known as embryoid bodies (EBs) is the principal step in the differentiation of pluripotent embryonic stem cells. Using c-Kit-positive hAFSC lines, researchers show here that these stem cells harbor the potential to form EBs. [Oncogene]

Systems-Level Dynamic Analyses of Fate Change in Murine Embryonic Stem Cells
Here scientists present a dynamic systems-level study of cell fate change in murine ESCs following a well-defined perturbation. [Nature]

MRPS18-2 Protein Immortalizes Primary Rat Embryonic Fibroblasts and Endows them with Stem Cell-Like Properties
The overexpression of mitochondrial ribosomal protein MRPS18-2 (S18-2) can immortalize primary rat embryonic fibroblasts (REFs). [PNAS]

Effective Generation of iPS Cells from CD34+ Cord Blood Cells by Inhibition of P53
Cord blood banks provide fully HLA typed cells from which a set of standard iPS cells for use in allogenic transplantation could be derived. Hence, the ability to generate iPS cells from cord blood cells has the potential to provide a suitable source for clinical transplantation. [Exp Hematol]

Characterization of Integrin Engagement During Defined Human Embryonic Stem Cell Culture
Researchers sought to identify which integrins hES cells exploit for adhesion to Matrigel-coated surfaces in defined medium conditions. [FASEB J]

Human Embryonic Stem-Cell Derivatives for Full Reconstruction of the Pluristratified Epidermis: A Preclinical Study
hESCs can be differentiated into basal keratinocytes that are fully functional-ie, able to construct a pluristratified epidermis. This resource could be developed to provide temporary skin substitutes for patients awaiting autologous grafts. [J Lancet]

Satb1 and Satb2 Regulate Embryonic Stem Cell Differentiation and Nanog Expression
In examining the role of Satb proteins in murine embryonic stem (ES) cells, researchers find that Satb1-/- cells display an impaired differentiation potential and augmented expression of the pluripotency determinants Nanog, Klf4, and Tbx3. [Genes & Dev]

Direct Hepatic Differentiation of Mouse Embryonic Stem Cells Induced by Valproic Acid and Cytokines
Hepatic cells of different developmental stages from early progenitors to matured hepatocytes can be acquired in the appropriate order based on sequential induction with VPA and cytokines. [World J Gastroenterol]

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INDUSTRY NEWS

Large Companies Still Looking for Acquisition Targets, Says Cutting Edge Information
In the past year, drug makers' thirst for innovation combined with small companies' dwindling operating capital to drive merger and acquisition activity. At the high end of the scale, consolidation among industry leaders created some of the richest pharmaceutical mergers in history.

POLICY NEWS

NIGMS Invests in Scientific Grand Opportunities with Recovery Act Funds
The National Institute of General Medical Sciences (NIGMS) is investing $42.3 million for grants in scientific areas it identified as "Grand Opportunities (GO)." NIH developed the GO grant program to stimulate biomedical research and the economy using funds provided by the American Recovery and Reinvestment Act (Recovery Act).

EVENTS

49th American Society for Cell Biology Annual Meeting
December 5-9, 2009
San Diego, United States

WiCell Human Embryonic Stem Cell Course
December 7-9, 2009
Madison, United States

Stem Cells and Regenerative Medicine World Congress
January 20-21, 2010
San Francisco, United States

Phacilitate Cell and Gene Therapy
January 25-27, 2010
Washington DC, United States

Molecular Medicine Tri-Conference 2010
February 3-5, 2010
San Francisco, United States

SMi's 2nd Annual Stem Cells
February 15-16, 2010
London, United Kingdom

Keystone Symposium B4 Stem Cell Differentiation and Dedifferentiation
February 15-20, 2010
Keystone, United States

Stem Cell Summit
February 16, 2010
New York, United States

16th Annual ISCT meeting
May 23-26, 2010
Philadelphia, United States

ISSCR 8th Annual Meeting
June 16-19, 2010
San Francisco, United States

JOB OPPORTUNITIES

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