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CURRENT PUBLICATIONS
Alternative Splicing in the Differentiation of Human Embryonic Stem Cells into Cardiac Precursors
To better define the role of alternative splicing in self-renewal, the researchers modified the H9 hESC line to allow selection of pluripotent hESCs by neomycin resistance and cardiac progenitors by puromycin resistance. [PLOS]
Interrogating Functional Integration Between Injected Pluripotent Stem Cell-derived Cells and Surrogate Cardiac Tissue
Using a cardiac tissue model, engineered heart tissue, and quantitative molecular and electrophysiological analyses, transplantation conditions and specific cell populations were tested for embryonic stem cells' potential to functionally integrate with the host tissue. [PNAS]
Coordination of Sonic Hedgehog and Wnt Signaling Determines Ventral and Dorsal Telencephalic Neuron Types from Human Embryonic Stem Cells
This study shows that human embryonic stem cells differentiate to telencephalic progenitors with a predominantly dorsal identity in a chemically defined medium without known morphogens. [Development]
Generation of Homogeneous PDX1+ Pancreatic Progenitors from Human ES Cell-derived Endoderm Cells
In this report, the researchers found that when the activin A-induced human embryonic stem cells were replated and seeded at low cell densities, the addition of retinoic acid induced significant pancreatic differentiation and over 70% of cells in culture expressed duodenal homeobox gene 1. [J Mol Cell Biol]
Activated Local Immunity by CCL19-Transduced Embryonic Endothelial Progenitor Cells Suppresses Metastasis of Murine Ovarian Cancer
The researchers in this study attempted to establish a novel therapeutic modality that targets tumor vessels of multiple metastases using embryonic EPCs transduced with an immune activating gene. [Stem Cells]
Excision of Reprogramming Transgenes Improves the Differentiation Potential of iPS Cells Generated with a Single Excisable Vector
This study demonstrates the efficient derivation of iPS cells free of exogenous reprogramming transgenes using an excisable polycistronic lentiviral vector. [Stem Cells]
Sphingosine 1-Phosphate Regulation of Extracellular Signal-Regulated Kinase-1/2 in Embryonic Stem Cells
The researchers here investigated the role of sphingosine 1-phosphate, a regulator in the self-renewal of human embryonic stem cells, in regulating ERK-1/2 signaling in mouse embryonic stem cells. [Stem Cells Dev]
Derivation of Human Embryonic Stem Cell Lines from Biopsied Blastomeres on Human Feeders with Minimal Exposure to Xenomaterials
In this study, the researchers describe an improved method for efficient derivation of hESC lines from blastomeres of biopsied embryos. [Stem Cells Dev]
Alginate Microcapsule for Propagation and Directed Differentiation of hESCs to Definitive Endoderm
The data from this study data shows that microcapsules can be used for differentiation of human embryonic stem cells into definitive endoderm in 3D and could have potential application for immune-isolation and prevention of teratomas formation of hESCs during transplantation. [Biomaterials]
Feeder-free Self-renewal of Human Embryonic Stem Cells in 3D Porous Natural Polymer Scaffolds
Here, the researchers demonstrate a strategy that supports sustained self-renewal of hESCs in a three-dimensional porous natural polymer scaffold, comprised of chitosan and alginate, without the support of feeder cells or conditioned medium. [Biomaterials]
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