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Scientists Make Active Motor Neurons from Induced Pluripotent Stem Cells
Stem cell scientists at UCLA showed for the first time that human induced pluripotent stem cells can be differentiated into electrically active motor neurons, a discovery that may aid in studying and treating neurological disorders.




SCIENCE

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Human Stem Cells Provide a New Model for Lou Gehrig's Disease
Overcoming the limited success of previous models, a report published in Disease Models & Mechanisms describes how neurons can be derived from human stem cells, and engineered to mimic inherited ALS.

Winners of the Stem Cell Image Contest Announced by the California Institute for Regenerative Medicine
The twelve winning images from the first California Institute for Regenerative Medicine stem cell image contest range from a whirling galaxy of developing nerve cells to a moonscape of retinal pigment epithelial cells, both derived from human embryonic stem cells.




ABSTRACTS

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Cells Extract from Fetal Liver Promotes the Hematopoietic Differentiation of Human Embryonic Stem Cells
This study describes a new inducing system to promote the differentiation of human stem cells toward hematopoietic lineages by the treatment with cells extract of human fetal liver tissue.

A Rosette-type, Self-renewing Human Embryonic Stem Cell-derived Neural Stem Cell with Potential for in Vitro Instruction and Synaptic Integration
Here, the researchers present a pure population of long-term self-renewing rosette-type hESC-derived neural stem cells (lt-hESNSCs), which exhibit extensive self-renewal, clonogenicity, and stable neurogenesis.

Neuronal Guidance Protein Netrin-1 Induces Differentiation in Human Embryonal Carcinoma Cells
This study suggests that Netrin-1 can induce neuroectodermal-like differentiation of human EC cells by affecting c-src signaling via SHP-2 activation and regulation of Nanog, Oct4, and Cripto-1 expressions.

p66ShcA Adaptor Molecule Accelerates Embryonic Stem Cell Neural Induction
The researchers in this report show that p66ShcA is up-regulated during in vitro neural induction in embryonic stem cells.




INDUSTRY

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Geron's Push to Europe Thwarted
Some of Geron's glow faded on Friday when the company realized that its worldwide license for its stem cell technology is not valid in Europe.

ParkwayHealth and Mesoblast to Provide Cutting Edge Treatment Using Proprietary Adult Stem Cells
Parkway Group Healthcare Pte Ltd and Mesoblast Limited recently announced a collaborative program to facilitate commercialization of Mesoblast's proprietary "off-the-shelf" stem cell products within the extensive ParkwayHealth hospital network in Asia.

Texan Governor Announced Emerging Technology Fund Investment in Stem Cell Research at Texas A and M Health Science Center
Governor Rick Perry announced a $5 million investment through the Texas Emerging Technology Fund to recruit leading scientists focused on regenerative medicine technologies to the Texas A and M Health Science Center College of Medicine Institute for Regenerative Medicine at Scott and White.

Oklahoma Funding for Adult Stem Cell Research Approved
Legislation that could provide nearly $2 million for adult stem cell research in Oklahoma received committee approval last week.

Senate Votes to Authorize Stem Cell Research
A bill authorizing embryonic stem cell research in New Mexico has been approved by the Senate recently.




POLICY

Industry Could Lose Battle over Language for Comparative Effectiveness Research
A House-Senate conference committee last night settled on a provision of the stimulus package that could be critical to the biotech and pharmaceutical industry in the coming years, nailing down the details of a $1.1 billion fund for comparative effectiveness research.

Cash Boost Coming for Stagnant U.S. Medical Research
After years of stagnant funding, medical research in the United States is set for a big cash infusion that experts expect will boost work on a range of ailments as well studies involving human embryonic stem cells.

F.D.A. Consolidates at Former Navy Site
The Food and Drug Administration has moved into the Naval Surface Warfare Center in White Oak, consolidating its previously scattered labs and offices.

Maryland Stem Cell Research Commission's Focus to Change
Maryland Stem Cell Research Commission members hashed out plans for the group's future Tuesday, as they discussed a new bill that would reorganize the commission to include biotechnology and change the purpose of the fund.



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