CURRENT PUBLICATIONS

Hematopoietic Cell Transplantation for Children with Acute Lymphoblastic Leukemia in Second Complete Remission: Similar Outcomes in Recipients of Unrelated Marrow and Umbilical Cord Blood versus Marrow from HLA Matched Sibling Donors
Results suggest the timing of hematopoietic cell transplantation (HCT) in children with Acute Lymphoblastic Leukemia (ALL) should be based primarily on the risk of relapse with conventional chemotherapy and not on the type of donor available. [Biol Blood Marrow Transplant]

The Notch Ligands Jagged2, Delta1, and Delta4 Induce Differentiation and Expansion of Functional Human NK Cells from CD34+ Cord Blood Hematopoietic Progenitor Cells
The use of Notch ligands to generate functional NK cells in vitro may be significant for cellular therapy purposes. [Biol Blood Marrow Transplant]

Stable Gene Transfer and Expression in Cord Blood-Derived CD34+ Hematopoietic Stem and Progenitor Cells by a Hyperactive Sleeping Beauty Transposon System
Researchers report stable gene transfer in cord blood-derived CD34+ hematopoietic stem cells using a hyperactive nonviral Sleeping Beauty (SB) transposase (SB100X). [Blood]

Reduced-Intensity Allogeneic Transplantation in Pediatric Patients Ineligible for Myeloablative Therapy: Results of the Pediatric Blood and Marrow Transplant Consortium Study ONC0313
Favorable outcomes can be achieved with reduced-intensity conditioning (RIC) approaches in pediatric patients in remission who are ineligible for myeloablative transplantation. [Blood]

Noninvasive Bioluminescent Imaging Demonstrates Long-Term Multilineage Engraftment of Ex Vivo-Expanded CD34-Selected Umbilical Cord Blood Cells
Results demonstrate that, other than a mild delay at the onset of engraftment, there were no significant differences in lineage repopulation or in long-term or secondary engraftment between culture-expanded and unexpanded UCB CD34-selected cells. [Stem Cells]

Pluripotency Can be Rapidly and Efficiently Induced in Human Amniotic Fluid-Derived Cells
Researchers report for the first time rapid and efficient generation of iPS cells from human amniotic fluid-derived cells (hAFDCs) via ectopic expression of four human factors: OCT4/SOX2/KLF4/C-MYC. [Hum Mol Genet]

CURRENT PUBLICATIONS

Hematopoietic Cell Transplantation for Children with Acute Lymphoblastic Leukemia in Second Complete Remission: Similar Outcomes in Recipients of Unrelated Marrow and Umbilical Cord Blood versus Marrow from HLA Matched Sibling Donors
Results suggest the timing of hematopoietic cell transplantation (HCT) in children with Acute Lymphoblastic Leukemia (ALL) should be based primarily on the risk of relapse with conventional chemotherapy and not on the type of donor available. [Biol Blood Marrow Transplant]

The Notch Ligands Jagged2, Delta1, and Delta4 Induce Differentiation and Expansion of Functional Human NK Cells from CD34+ Cord Blood Hematopoietic Progenitor Cells
The use of Notch ligands to generate functional NK cells in vitro may be significant for cellular therapy purposes. [Biol Blood Marrow Transplant]

Stable Gene Transfer and Expression in Cord Blood-Derived CD34+ Hematopoietic Stem and Progenitor Cells by a Hyperactive Sleeping Beauty Transposon System
Researchers report stable gene transfer in cord blood-derived CD34+ hematopoietic stem cells using a hyperactive nonviral Sleeping Beauty (SB) transposase (SB100X). [Blood]

Reduced-Intensity Allogeneic Transplantation in Pediatric Patients Ineligible for Myeloablative Therapy: Results of the Pediatric Blood and Marrow Transplant Consortium Study ONC0313
Favorable outcomes can be achieved with reduced-intensity conditioning (RIC) approaches in pediatric patients in remission who are ineligible for myeloablative transplantation. [Blood]

Noninvasive Bioluminescent Imaging Demonstrates Long-Term Multilineage Engraftment of Ex Vivo-Expanded CD34-Selected Umbilical Cord Blood Cells
Results demonstrate that, other than a mild delay at the onset of engraftment, there were no significant differences in lineage repopulation or in long-term or secondary engraftment between culture-expanded and unexpanded UCB CD34-selected cells. [Stem Cells]

Pluripotency Can be Rapidly and Efficiently Induced in Human Amniotic Fluid-Derived Cells
Researchers report for the first time rapid and efficient generation of iPS cells from human amniotic fluid-derived cells (hAFDCs) via ectopic expression of four human factors: OCT4/SOX2/KLF4/C-MYC. [Hum Mol Genet]

POLICY NEWS

FOOD AND DRUG ADMINISTRATION (United States)

Access to Investigational Drugs

2009 Meeting Materials, Vaccines and Related Biological Products Advisory Committee

NATIONAL INSTITUTES OF  HEALTH (NIH)

Directed Stem Cell Differentiation for Cell-Based Therapies for Heart, Lung, and Blood Diseases

Vaccines and Related Biological Products Advisory Committee Meeting Announcement

Francis S. Collins, M.D., Ph.D., Sworn in as NIH Director
He was nominated to lead the NIH, the nation's premiere biomedical research agency, by President Barack Obama on July 8, and was unanimously confirmed by the U.S. Senate on August 7.

Bioethecist R. Alta Charo Comes To FDA After Stints On IoM Drug Safety Group, NIH Embryo Research Panel
She's joining FDA as a senior advisor, reporting to Assistant Commissioner for Policy David Horowitz.

Events

2nd TERMIS World Congress In Conjunction With 2009 Seoul Stem Cell Symposium
August 31-September 3, 2009
Seoul, South Korea

XXXVI Annual Meeting of the European Society for Artificial Organs 2009   
September 2-5, 2009
Compiègne, France

16th International Society of Developmental Biologists Congress
September 6-10, 2009
Edinburgh, United Kingdom

International Society for Hematology and Stem Cells 38th Annual Scientific Meeting
September 9-12, 2009
Athens, Greece

51st ASH Annual Meeting and Exposition
December 9-12, 2009
New Orleans, LA

2010 BMT Tandem Meetings
February 24-28, 2010
Orlando, Florida

The European Group for Blood & Marrow Transplantation Annual Meeting
March 21-24, 2010
Vienna, Austria

Canadian Blood and Marrow Transplant Consortium Annual Meeting
April 7-10, 2010
Vancouver, BC

16th Annual International Society for Cellular Therapy Meeting
May 22-26, 2010
Philadelphia, Pennsylvania

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.

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