Scientists showed that intestinal-epithelial intrinsic expression of lysine-specific demethylase 1A (LSD1) was necessary for the postnatal maturation of intestinal epithelium and maintenance of this...

[Cancer Research] To provide insights into the molecular mechanisms regulating IL1A expression in PDAC, researchers performed transcriptional profiling of The Cancer Genome Atlas datasets and pharmacologic screening in PDAC cells and identified p38α MAPK as a key positive regulator of IL1A expression.

[Molecular And Cellular Biochemistry] Scientists introduce the development of functional β-cells and their heterogeneity and then turn to highlight recent advances in the generation of β-cells from stem cells and their potential applications in disease modeling, drug discovery and clinical therapy.

[Molecular Psychiatry] Scientists replicated the altered corticogenesis in the Huntington's disease (HD) fetal brain using HD patient-derived human cortical organoids (hCOs). Our HD-hCOs had pathological phenotypes, including deficient junctional complexes in the neural tubes, delayed postmitotic neuronal maturation, dysregulated fate specification of cortical neuron subtypes, and abnormalities in early HD subcortical projections during corticogenesis.

[Cell Death & Disease] Investigators revealed that Cldn-7 deletion disrupts the self-renewal and differentiation of colonic stem cells alongside the formation of colonic organoids in vitro. Additionally, these Cldn-7 knockout models exhibited heightened susceptibility to experimental colitis, limited epithelial repair and regeneration, and increased differentiation toward the secretory lineage.

[Signal Transduction And Targeted Therapy] Researchers utilized islet organoids derived from human embryonic stem cells, animal models, and COVID-19 patients to discover that fibroblast growth factor 7 (FGF7) enhanced ACE2 expression within the islets, facilitating SARS-CoV-2 infection and resulting in impaired insulin secretion.

[Nature Communications] Using colorectal cancer patient-derived organoids, investigators found that compared to LGR5- cells, LGR5+ cancer stem cells were stiffer, adhered better to the extracellular matrix, moved slower both as single cells and clusters, displayed higher nuclear YAP, showed a higher survival rate in response to mechanical confinement, and form larger transendothelial gaps.

[Cell Death & Disease] Researchers used intestinal epithelial cells- and intestinal stem cells-specific Cldn-7 knockout mice to investigate the regulatory effects of Cldn-7 on colonic Lgr5+ stem cells in the mediation of colonic epithelial injury and repair under physiological and inflammatory conditions.

[Stem Cell Reviews And Reports] Scientists focused on stem cell related methodologies, such as organoids, that could serve as an alternative to animal testing and discuss its advantages and limitations, alongside regulatory considerations.

[Biomedicine & Pharmacotherapy] The authors describe the regulatory mechanism of the miRNA-192 family affecting the malignant behavior of breast cancer cells and evaluate the value of the miRNA-192 family as a diagnostic and prognostic biomarker for breast cancer.

[Evexta Bio SA] Evexta Bio SA provided an update on the clinical development of its lead asset, rupitasertib, a selective oral inhibitor of S6K and AKT1/AKT3.

[Journal Of Controlled Release] The authors present the interactions among the immune system, intestinal barrier, and gut microbiome. In addition, recent advances in administration routes and methods that positively arouse the regulation of intestinal flora for inflammatory bowel disease using probiotics, prebiotics, and redox-active micro/nanomaterials have been reviewed.