Keep Current with the Latest in Cell Biology Research

Transcriptomic and Cellular Decoding of Scaffolds-Induced Suture Mesenchyme Regeneration

[International Journal Of Oral Science] Investigators' data elucidated the natural processes without scaffold transplantation and demonstrated how different scaffolds altered in vivo cellular responses.

Mesenchymal Stem Cells Derived-Exosomes Enhanced Amniotic Membrane Extract Promotes Corneal Keratocyte Proliferation

[Biotechnology Progress] The authors evaluated the effects of both amniotic membrane extract and Wharton's jelly MSC derived-exosomes, individually and together, on the proliferation of corneal keratocytes as well as their ability to promote in vitro cell migration, wound healing, and their impact on cellular morphology.

PPARγ Inhibition Promotes Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells and Fracture Healing

[Journal Of Cellular Biochemistry] Bone healing processes in the rat femur fracture model were recorded and assessed by radiographic methods on Weeks 8, 14, and 20 postoperation.

NIH Grant Supports Additional Baby Metabolism Research

[East Carolina University] A five-year, $2.5 million R01 grant from the National Institutes of Health will help East Carolina University faculty members continue research on ways to curb generational obesity.

Mesenchymal Stem Cells as Therapeutic Vehicles for Glioma

[Cancer Gene Therapy] MSCs exhibit advantages for glioma therapy because of their ability to pass through the blood–brain barrier and migrate to tumor cells and their tolerance to the immune system.

LncRNA MIR210HG Promotes Phenotype Switching of Pulmonary Arterial Smooth Muscle Cells through Autophagy-Dependent Ferroptosis Pathway

[Apoptosis] Investigators identified for the first time the potential effect of MIR210HG on disease progression in hypoxic pulmonary hypertension.

Progress of Mitochondrial Function Regulation in Cardiac Regeneration

[Journal Of Cardiovascular Translational Research] The authors review mitochondria's multifaceted role in cardiac regeneration, particularly in myocardial infarction and heart failure models.

Mitochondrial tRNA Pseudouridylation Governs Erythropoiesis

[Blood] Researchers investigated the role of tRNA pseudouridylation in erythropoiesis and its association with mitochondrial myopathy, lactic acidosis, and sideroblastic anemia syndrome pathogenesis.

Integrative Single-Cell Chromatin and Transcriptome Analysis of Human Plasma Cell Differentiation

[Blood] Scientists combined single cell RNA-seq and single cell ATAC-seq to decipher the trajectories involved in plasma cell differentiation.

Detection of Newly Synthesized RNA Reveals Transcriptional Reprogramming during ZGA and a Role of Obox3 in Totipotency Acquisition

[Cell Reports] The authors developed a method to capture and sequence newly synthesized RNA in early mouse embryos, providing a view of transcriptional reprogramming during zygotic genome activation.

Phototoxicity Avoidance Is a Potential Therapeutic Approach for Retinal Dystrophy Caused by EYS Dysfunction

[JCI Insight] Scientists generated retinal organoids from iPSCs derived from patients with eyes shut homolog (EYS)-associated retinal dystrophy.

Chromatin Landscape Instructs Precise Transcription Factor Regulome during Embryonic Lineage Specification

[Cell Reports] Researchers delineated the dynamics of TFAP2C during the mouse peri-implantation stage and elucidated its collaboration with the key lineage regulators CDX2 and NANOG.

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