[Circulation] The authors leveraged 2 models of in vitro cultured adult mouse cardiomyocytes and in vivo adeno-associated virus serotype 9 cardiomyocyte–targeted delivery of reprogramming factors in adult mice to study cardiomyocyte dedifferentiation.

[eLife] Researchers developed a 96-well plate assay which allowed fast, reproducible, and high-throughput generation of three dimensional cardiac rings around a deformable optically transparent hydrogel pillar of known stiffness.

[Signal Transduction and Targeted Therapy] Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) subjected to space microgravity showed decreased beating rate and abnormal intracellular calcium cycling. Metabolomic and transcriptomic analyses revealed a battery of metabolic remodeling of hPSC-CMs in spaceflight, especially thiamine metabolism.

[Scientific Reports] Scientists employed miRNA microarray analysis to investigate the expression profile of miRNAs in skeletal muscle from an animal model of hypoxia-induced muscle atrophy and resistance training aimed at mitigating muscle atrophy.

[Scientific Reports] The authors harnessed publicly available human carotid atherosclerotic data to explore radical S-adenosyl-L-methionine domain containing 2 (RSAD2) in lesions and employed siRNA-mediated gene-knockdown to investigate its function in interferon gamma-stimulated human aortic smooth muscle cells.

[Arteriosclerosis Thrombosis And Vascular Biology] Spontaneously hypertensive rats and newly generated smooth muscle–specific AKAP150 knockin mice were used to assess the role of myocyte AKAP150/CaV1.2 channel in regulating cerebral artery function after exercise intervention.

[Molecular Medicine Reports] The authors lay a foundation for the development of novel treatment options for individuals affected by muscular atrophy, and explore other regulatory pathways, such as autophagy and inflammatory signaling.

[NASA Blogs] Advanced space biology continued aboard the International Space Station to develop and test therapies for a range of space-caused and Earthbound health conditions.

[Neuron] Using in vivo genetic studies in mice, scRNA-seq, and functional validation, researchers showed that deep plexus angiogenesis and paracellular blood-retinal barrier maturation were delayed in Vglut1−/− retinas where neurons failed to release glutamate.

[Cell Communication and Signaling] The authors investigated the molecular mechanism underlying endomucin’s involvement in the regulation of vascular endothelial growth factor-induced endocytosis.

[Signal Transduction and Targeted Therapy] Investigators verified that anlotinib, a tyrosine kinase inhibitor with anti-lymphangiogenesis activity, and SAR131675, a selective VEGFR-3 inhibitor, effectively decreased the density of tumor lymphatic vessels in mouse cancer models.

[Nature Reviews Cardiology] Scientists summarize the classical and the emerging non-classical roles of the complement system in the pathogenesis of atherosclerosis.