Keep Current with the Latest in Cell Biology Research

TGR5-Mediated Lateral Hypothalamus-dCA3-Dorsolateral Septum Circuit Regulates Depressive-Like Behavior in Male Mice

[Neuron] Using depression models of chronic social defeat stress and chronic restraint stress in male mice, researchers found that TGR5 in the lateral hypothalamic area predominantly decreased in GABAergic neurons, the excitability of which increased in depressive-like mice.

Feedforward and Feedback Mechanisms Cooperatively Regulate Rapid Experience-Dependent Response Adaptation in a Single Thermosensory Neuron Type

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Researchers showed that rapid thermosensory response adaptation in AFD was mediated via cGMP and calcium-dependent feedforward and feedback mechanisms operating at the level of primary thermotransduction.

Glucosylceramide Accumulation in Microglia Triggers STING-Dependent Neuroinflammation and Neurodegeneration in Mice

[Science Signaling] Scientists investigated the mechanisms by which glucosylceramide (GC) accumulation induced neuroinflammation. They found that GC accumulation within microglia induced by pharmacological inhibition of GCase triggered STING-dependent inflammation, which contributed to neuronal loss both in vitro and in vivo.

Prosaposin Maintains Adult Neural Stem Cells in a State Associated with Deep Quiescence

[Stem Cell Reports] Using RNA sequencing and pharmacological manipulations, investigators showed that lysosomes were necessary for neural stem cell quiescence maintenance.

The Dynamics of Notch Signaling in the Neuron-Glia Switch: A Balancing Act

[Journal Of Neurophysiology] The author offersseveral suggestions for future research investigating the precise spatiotemporal control of Notch signaling throughout the development of the central nervous system.

Genetically Engineered Marmosets Promise Insight into Early Stages of Parkinson’s

[Science] A cohort of transgenic marmoset models may help predict neurological conditions and test potential treatments.

Dux Activates Metabolism-Lactylation-MET Network during Early iPSC Reprogramming with Brg1 as the Histone Lactylation Reader

[Nucleic Acids Research] Scientists demonstrated that the modification of H3K18la induced by Dux overexpression controlled the metabolism-H3K18la-MET network, enhancing the efficiency of iPSC reprogramming through a metabolic switch and the recruitment of p300 via its C-terminal domain.

Preparation of Human Astrocytes with Potent Therapeutic Functions from Human Pluripotent Stem Cells Using Ventral Midbrain Patterning

[Journal of Advanced Research] To substantiate the clinical application of astrocyte-based therapy, researchers prepared human astrocytes with potent therapeutic capacities from hPSCs. They used ventral midbrain patterning during the differentiation of hPSCs into astrocytes.

Matrix-Free Human Pluripotent Stem Cell Manufacturing by Seed Train Approach and Intermediate Cryopreservation

[Stem Cell Research & Therapy] Stirred tank bioreactors-controlled, chemical aggregate dissociation, and optimized passage duration of three or four days promoted exponential hPSC proliferation, process efficiency, and upscaling by a seed train approach.

Spatial Cell Fate Manipulation of Human Pluripotent Stem Cells by Controlling the Microenvironment Using Photocurable Hydrogel

[Development] Investigators cultured hPSCs on hydrogel substrates with spatially controlled stiffness. The use of culture substrates that enabled precise manipulation of spatial mechanical properties held promise for better mimicking in vivo conditions and advancing tissue engineering techniques.

Diverting the Food-Freezing Technology Improves the Cryopreservation Efficiency of Induced Pluripotent Stem Cells and Derived Neurospheres

[Regenerative Therapy] Scientists evaluated the efficiency of cryopreservation using DEPAK and Proton freezers, both of which are used in the food industry, compared with conventional slow-freezing methods using a programmable freezer and a cell-freezing vessel.

Rbm46 Inhibits Reactive Oxygen Species in Mouse Embryonic Stem Cells through Modulating BNIP3-Mediated Mitophagy

[Biochemical and Biophysical Research Communications] The authors revealed the pivotal role of RNA-binding motif protein 46 (RBM46) in ESCs, acting as a direct post transcriptional regulator of ROS levels by modulating BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (Bnip3) mRNA expression.

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