Researchers demonstrated the feasibility of incorporating multisector sampling in cancer vaccine design and provided information on the clinical applicability of clonality, distribution, and immunogenicity...

[Molecular Therapy] The authors revealed seven distinct immune cell types including myeloid-derived suppressor cells in the CD11bmidLy6Cmid cells, while CD11bhiLy6Chi cells included mostly monocytes/macrophages with a small cluster of neutrophils.

[Molecular Cancer Therapeutics] Investigators reported leukocyte-associated immunoglobulin-like receptor 1 was associated with tumor stroma and was highly expressed by intratumoral myeloid cells in both human tumors and mouse models of cancer.

[Advanced Science] Researchers revealed, for the initial time, the significant enhancement of mucosal and cutaneous wound healing by membrane vesicles secreted by the human commensal Lactobacillus reuteri through modulation of the inflammatory environment in wound tissue.

[Journal Of Autoimmunity] Scientists reported CD318 expression in a subpopulation of CD318+ myeloid dendritic, whereas the other peripheral blood populations were CD318 negative.

[Retrovirology] Investigators assessed the level of human endogenous retrovirus W (HERV-W)-env expression and the systemic inflammatory profile through the concentration of IL-2, IL-4, IL-6, IL-10, TNF-α and INF-γ cytokines in bipolar disorder and schizophrenia patients.

[Blood Advances] Researchers showed that human leukocyte antigen knockout (HLA KO) does not alter T-cell functionality in vitro and in vivo. While HLA KO abrogated allogeneic T-cell responses, it elicited NK-cell recognition. To circumvent this problem, they demonstrated that selective editing of individual HLA class I molecules in primary human T cells was possible.

[Clinical Immunology] Scientists performed single-cell RNA sequencing of peripheral blood and bone marrows and bone marrow mononuclear cells from severe aplastic anemia patients and healthy donors and identified a CD8+ T cell subset with a tissue residency phenotype (Trm) in bone marrow that exhibited high IFN-γ and FasL expression and have a higher ability to induce apoptosis in hematopoietic stem and progenitor cells in vitro through FasL expression.

[Lancet] The authors discuss a diagnostic approach to symptoms in light of the latest classification criteria, which include a systematic evaluation of clinical manifestations and autoantibody profiles.

[Sandoz] Sandoz announces that the European Commission has granted marketing authorization for Pyzchiva® (biosimilar ustekinumab), developed and registered by Samsung Bioepis.

[Scientific Reports] Researchers found that platelet-activating factor acetylhydrolase IB3 (PAFAH1B3) was highly expressed in pancreatic cancer tissues and cells. In vitro and in vivo studies showed that overexpression of PAFAH1B3 promoted the proliferation and invasion of pancreatic cancer cells, while downregulation of PAFAH1B3 inhibited these processes.

[Discover Oncology] Investigators explored the roles and mechanisms of leucine rich repeat of flightless-1 interacting protein 1 (LRRFIP1) in pancreatic cancer. The influences of LRRFIP1 on the proliferation and migration of pancreatic cancer cells were assessed in vitro.