Keep Current with the Latest in Cell Biology Research

Myosin-Binding Protein C Regulates the Sarcomere Lattice and Stabilizes the OFF States of Myosin Heads

[Nature Communications] Investigators used a combination of mechanics and small-angle X-ray diffraction to study the immediate and selective removal of the myosin-binding protein C (MyBP-C) C1C7 domains of fast MyBP-C in permeabilized skeletal muscle.

MST1/2 Regulates Fibro/Adipogenic Progenitor Fate Decisions in Skeletal Muscle Regeneration

[Stem Cell Reports] Using inducible conditional knockout mice, the authors showed that blocking mammalian Ste20-like kinases 1/2 (MST1/2) of fibroblast/adipose progenitors prevented apoptosis and reduced interleukin-6 secretion in vivo and in vitro.

Yin Yang 1 Regulates Cohesin Complex Protein SMC3 in Mouse Hematopoietic Stem Cells

[Blood Advances] Researchers found that Yin Yang 1 (YY1) physically interacted with structural maintenance of chromosomes 3 (SMC3) and co-occupied with SMC3 at a large cohort of promoters genome-wide, and YY1 deficiency deregulated the genetic network governing cell metabolism.

Interaction of Acetylcholine and Oxytocin Neuromodulation in the Hippocampus

[Neuron] The authors investigated the interaction of acetylcholine and oxytocin at slow and fast timescales during various brain states.

APP Antisense Oligonucleotides Reduce Aβ Aggregation and Rescue Endolysosomal Dysfunction in Alzheimer’s Disease

[Brain] Researchers found that antisense oligonucleotides targeting APP are an effective approach to reduce APP protein levels and rescue endolysosome and autophagy dysfunction in APP duplication human induced pluripotent stem cell-derived cortical neurons.

Retinoblastoma-Associated Protein Is Important for TRIM24-Mediated Activation of the mTOR Signaling Pathway through DUSP2 Action in Prostate Cancer

[Cell Death & Differentiation] Scientists found that the S249/T252 site in RB transcriptional corepressor 1 was key to regulating the transcriptional activity of the tumor-promoting factor TRIM24 in CRPC, as identified through FXXXV mapping.

Thermal Proteome Profiling Strategy Identifies CNPY3 as a Cellular Target of Gambogic Acid for Inducing Prostate Cancer Pyroptosis

[Journal Of Medicinal Chemistry] By using a thermal proteome profiling strategy, investigators revealed that gambogic acid induced pyroptosis by directly targeting the canopy FGF signaling regulator (CNPY3.)

Combined Therapy Targeting AR and EZH2 Curbs Castration-Resistant Prostate Cancer Enhancing Anti-Tumor T-cell Response

[Epigenomics] The authors investigated in vitro and in subcutaneous and spontaneous mouse models the effects of combining enzalutamide and GSK-126, a drug inhibiting the epigenetic modulator EZH2.

Biofilm Exopolysaccharides Alter Sensory-Neuron-Mediated Sickness during Lung Infection

[Cell] Investigators compared exopolysaccharide-producers versus non-producers and a virulent Escherichia coli lung infection model in male and female mice.

KN046, a Bispecific Antibody against PD-L1 and CTLA-4, Plus Chemotherapy as First-Line Treatment for Metastatic NSCLC: A Multicenter Phase II Trial

[Cell Reports Medicine] In this multicenter phase II trial, patients with nonsquamous (non-sq) NSCLC receive pemetrexed, whereas those with sq-NSCLC receive paclitaxel, plus KN046 and carboplatin. Following four cycles, maintenance therapy included KN046 with pemetrexed for non-sq-NSCLC and KN046 for sq-NSCLC.

Activation of Polyamine Catabolism Promotes Glutamine Metabolism and Creates a Targetable Vulnerability in Lung Cancer

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Scientists reported that activation of polyamine catabolism promoted glutamine metabolism, leading to a targetable vulnerability in lung cancer.

Enigmatic Exosomal Connection in Lung Cancer Drug Resistance

[Molecular Therapy - Nucleic Acids] Investigators summarize the current knowledge on conventional and emerging drug resistance mechanisms and the involvement of exosomes as well as exosome-mediated factors mediating drug resistance in lung cancer.

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